Antxr1 Antibody

1. Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting. PMID: 27555325
2. An essential physiologic role for Antxr1 in arteriogenesis and peripheral artery disease. PMID: 26785120
3. Data demonstrate that TEM8 is an essential regulator of connective tissue homeostasis. it controls synthesis of major matrix components in both endothelial and fibroblastic cells and regulates signaling pathways and matrix degradation. PMID: 25572963
4. Anthrax toxin receptors in mouse and human macrophages were silenced using targeted siRNAs or blocked with specific antibody prior to challenge with anthrax lethal toxin. PMID: 24742682
5. These results strongly suggest that TEM8 is the only minor anthrax toxin receptor mediating direct lethality in vivo and that other proteins implicated as receptors do not play this role. PMID: 23271637
6. This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection. PMID: 15689409
7. The mRNA transcripts of both receptors, ANTXR1 and ANTXR2 were detected in J774A.1 cells and mouse tissues suggesting that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells. PMID: 17459655
8. Data show that the lethality of anthrax toxin for mice is mostly mediated by CMG2 and that TEM8 plays only a minor role. PMID: 19617532
9. Host-derived TEM8 promotes the growth of certain tumors. PMID: 19622764

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KEGG: mmu:69538

STRING: 10090.ENSMUSP00000045634

UniGene: Mm.232525