Ass1 Antibody

1. findings uncover a new function of p53 in the regulation of Akt signaling and reveal how p53, ASS1, and Akt are interrelated to each other. PMID: 28560349
2. ASS1 acetylation by CLOCK exhibits circadian oscillation in human cells and mouse liver, possibly caused by rhythmic interaction between CLOCK and ASS1, leading to the circadian regulation of ASS1 and ureagenesis. PMID: 28985504
3. In diabetic mice, ablation of Ass resulted in diminished endothelium-derived nitric oxide-mediated vascular relaxation responses. PMID: 25033204
4. cAMP-induced Ass1 expression is important in controlling the magnitude of decidualization through regulating L-Arg level. PMID: 24556046
5. may contribute to liver injury by enhancing nitrosative stress PMID: 24224890
6. We demonstrate that the transgenic mouse system reported here has the merit of sensitivity and direct visualization advantage, and is ideal for annotating temporal and spatial expression profiles and the regulation mode of the ASS gene. PMID: 24884799
7. Thus, extracellular arginine fuels rapid NO production in activated macrophages, and citrulline recycling via Ass1 and Asl is a fail-safe system that sustains optimum NO production. PMID: 22980328
8. Partial argininosuccinate synthase ablation protects only in acute ethanol-induced liver injury by decreasing nitrosative stress but not in a more chronic scenario where oxidative stress and impaired fatty acid beta-oxidation are key events. PMID: 22213272
9. Loss of Ass1 is associated with citrullinemia type I and other hyperammonemic syndromes. PMID: 20724589
10. Argininosuccinate synthetase has a role in preventing autotoxicity from nitric oxide overproduction PMID: 15192091

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KEGG: mmu:11898

STRING: 10090.ENSMUSP00000099904

UniGene: Mm.3217