rfp-1 Antibody

Code CSB-PA330367XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans rfp-1 Polyclonal antibody
Uniprot No.
Target Names
rfp-1
Alternative Names
rfp-1 antibody; bre-1 antibody; R05D3.4E3 ubiquitin-protein ligase bre-1 antibody; EC 2.3.2.27 antibody; RING finger protein rfp-1 antibody; RING-type E3 ubiquitin transferase bre-1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans rfp-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Involved in regulating stem cell proliferative fate.
Gene References into Functions
  1. Lack of RFP-1 expression increases levels of MRG-1 and a shift towards increased proliferation in sensitized genetic backgrounds. PMID: 25564623
Subcellular Location
Nucleus.
Protein Families
BRE1 family
Tissue Specificity
In adult animals, expressed in oocytes, germ cells, pharyngeal and intestinal cells.
Database Links

KEGG: cel:CELE_R05D3.4

STRING: 6239.R05D3.4b

UniGene: Cel.20646

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