CCC1 Antibody

Code CSB-PA341728XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CCC1 Polyclonal antibody
Uniprot No. P47818
Target Names CCC1
Alternative Names CCC1; YLR220W; L8083.6; Protein CCC1; Cross-complementer of CSG1 protein 1
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CCC1 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals.
Gene References into Functions
  1. The identification of multiple independent transcriptional pathways that regulate the levels of Ccc1 under high iron conditions accentuates the importance of protecting cells from the toxic effects of high iron PMID: 29043483
  2. Data suggest that SNF1 deletion acts synergistically with YAP5 deletion to regulate transcription of vacuolar iron importer CCC1 and to regulate iron resistance; SNF1 deletion with MSN2/MSN4 deletion results in additive effects on CCC1 transcription. (SNF1 = sucrose non-fermenting kinase 1; YAP5 = transcription factor YAP5; CCC1 = Ca(II)-sensitive cross-complementer 1; MSN = stress-responsive transcriptional activator) PMID: 28760824
Subcellular Location Golgi apparatus membrane. Vacuole membrane; Multi-pass membrane protein.
Protein Families CCC1 family
Database Links

KEGG: sce:YLR220W

STRING: 4932.YLR220W

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