cftr Antibody

Code CSB-PA282472XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) cftr Polyclonal antibody
Uniprot No.
Target Names
cftr
Alternative Names
cftrCystic fibrosis transmembrane conductance regulator antibody; EC 5.6.1.6 antibody; ATP-binding cassette sub-family C member 7 antibody; Channel conductance-controlling ATPase antibody; cAMP-dependent chloride channel antibody
Raised in
Rabbit
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) cftr protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Required for normal fluid homeostasis in the gut. Required for normal volume expansion of Kupffer's vesicle during embryonic development and for normal establishment of left-right body patterning. Required for normal resistance to infection by P.aeruginosa strain PA14 and strain SMC573.
Gene References into Functions
  1. study revealed an important role of cystic fibrosis transmembrane conductance regulator (CFTR) acting as an ion channel in regulating primordial germ cell migration during early embryogenesis PMID: 29930176
  2. Molecular dynamics of the cryo-EM CFTR structure PMID: 28774558
  3. Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening. PMID: 28735752
  4. Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis-causing missense mutational sites are identical. PMID: 27912062
  5. Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis of the human pancreas. PMID: 25592226

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Subcellular Location
Apical cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
ABC transporter superfamily, ABCC family, CFTR transporter (TC 3.A.1.202) subfamily
Tissue Specificity
Detected in gut epithelium (at protein level). Detected in kidney, spleen, intestine and liver. Detected in pancreatic duct epithelium at 5 dpf and throughout adult life.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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