ctp1 Antibody

1. CtIP/Ctp1/Sae2/Com1 role in removal of DNA double strand breaks through DSB repair by homologous recombination is reviewed. PMID: 28623092
2. a mre11 mutant defective in endonucleolytic activity, the same mutant lacking Ctp1, or the triple mutant also lacking the putative hairpin nuclease Pso2 showed wild-type levels of repair. Thus, MRN (Mre11-Rad50-Nbs1)may act to recruit the hairpin opening activity that allows subsequent repair PMID: 28292918
3. The authors concludes that the intracellular Ctp1 C-terminal portion is essential for clipping, while the N-terminal portion is sufficient for DNA double-strand break end-resection. PMID: 26130711
4. Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair. PMID: 25580577
5. these data propose that release of the MRN complex and Ku from DNA ends by Mre11 nuclease activity and Ctp1 is a critical step required to expose ssDNA for replication protein A localization and ensuing homologous recombination repair. PMID: 21931565
6. In fission yeast, found only one class of oligonucleotides bound to Rec12 ranging in length from 17 to 27 nucleotides. Ctp1, Rad50, and the nuclease activity of Rad32, the fission yeast homolog of Mre11, are required for endonucleolytic Rec12 removal. PMID: 19911044
7. These data suggest that regulation of Ctp1 underlies cell-cycle control of homologous recombination. PMID: 17936710
8. This study demonstrates for the first time that Mre11 (Schizosaccharomyces pombe Rad32(Mre11)) nuclease activity is required for the removal of Rec12(Spo11). PMID: 19139281
9. Schizosaccharomyces pombe Rad32(Mre11) nuclease activity is involved in the removal of both Top2 from 5' DNA ends as well as Top1 from 3' ends in vivo and a ctp1(CtIP) deletion is defective for Top2 removal but overproficient for Top1 removal. PMID: 19150433
10. The Mre11-Rad50-Nbs1 S-phase checkpoint role is separate from its Ctp1- and resection-dependent role in double-strand break repair. PMID: 19211838
11. Study finds that in the presence of the MRN (Rad32-Rad50-Nbs1) complex efficient recombination requires Ctp1, the ortholog of the nuclease Sae2, but not the nuclease activity of MRN. PMID: 19470480
12. Rad32 nuclease has the catalytic site for Rec12-oligonucleotide generation and is activated by Ctp1, which plays an additional role in meiotic recombination. PMID: 19752195
13. Tethering of Ctp1 to a flexible Nbs1 arm suggests a mechanism for restricting DNA end processing and homologous recombination activities of Sae2/Ctp1/CtIP to the immediate vicinity of double-strand breaks. PMID: 19804755

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KEGG: spo:SPCC338.08

STRING: 4896.SPCC338.08.1