CASK Antibody

Code CSB-PA632578XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) CASK Polyclonal antibody
Uniprot No.
Target Names
CASK
Alternative Names
CASK antibody; Caki antibody; cmg antibody; CG6703Peripheral plasma membrane protein CASK antibody; dCASK antibody; EC 2.7.11.17 antibody; Calcium/calmodulin-dependent protein kinase antibody; CAKI antibody; Camguk antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) CASK protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.
Gene References into Functions
  1. Data show that Drosophila CASK is associated with both pre and postsynaptic membranes, and that loss of presynaptic CASK leads to less evoked synaptic transmission, fewer spontaneous synaptic events, and reduced synaptic vesicle cycling. PMID: 21820054
  2. Full-length CASK-beta appears to have a unique role within central circuits that control motor output PMID: 21059886
  3. Camguk localizes to synaptic regions of the brain and associates in an ATP-regulated manner with CaMKII to catalyze formation of a pool of calcium-insensitive CaMKII. PMID: 14687552
  4. The results of this study support the involvement of CAKI in neurotransmitter release and nervous system function. PMID: 15872064
  5. the Drosophila homolog of CASK/Camguk can act as a gain controller on the transition to calcium-independence in vivo. PMID: 16880127
  6. Dneurexin (DNRX) is important for locomotion through a genetic interaction with the scaffold protein, CAKI/CMG, the Drosophila homolog of vertebrate CASK. PMID: 19379781

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Subcellular Location
Cell membrane; Peripheral membrane protein. Note=Eag recruits CASK to the plasma membrane.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily; MAGUK family
Tissue Specificity
During embryogenesis, larval and pupal life, found almost exclusively in the central nervous system. In the adult head found in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain.
Database Links

KEGG: dme:Dmel_CG6703

STRING: 7227.FBpp0303394

UniGene: Dm.7404

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