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Commd5 Antibody

Datasheet
Code CSB-PA880645ZA01RA
Size
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Commd5 Polyclonal antibody
Uniprot No.
Q9ERR2
Target Names
Commd5
Alternative Names
COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG), Commd5
Raised in
Rabbit
Species Reactivity
Rattus norvegicus
Immunogen
Recombinant Rattus norvegicus Commd5 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugate
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

Commd5 Proteins

Customer Reviews and Q&A

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Target Background

Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
Gene References into Functions
  1. Hcarg localizes to the rat chromosome 7 between the markers Mit3 and Mit4. We identified a BglII RFLP between BN.lx and SHR rats. PMID: 11871861
  2. HCaRG regulates renal epithelial cell growth and differentiation causing G(2)M cell cycle arrest PMID: 12620924
  3. data support a role for HCaRG in kidney repair after injury through its effect on renal cell migration and TGF-alpha secretion PMID: 16033922
  4. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer. PMID: 18949406
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in the zona fasciculata and medulla of the adrenal gland; expressed in kidney proximal tubules. Basal expression is higher in hypertensive than in normotensive animals.
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