DBF4 Antibody

1. Dbf4 interacts directly with Sld3 and promotes the recruitment of downstream limiting factors. PMID: 29330352
2. The scaffold protein Rtt107, which binds the Mus81-Mms4 complex, interacts with Cdc7 and thereby targets Cdc7-Dbf4 and Cdc5 to the complex enabling full Mus81 activation. PMID: 28096179
3. The Rad53-Dbf4 interaction is phosphorylation-independent and involves a novel non-canonical interface on the FHA1 domain. PMID: 24285546
4. Dbf4 phosphorylation requires physical interaction of Dbf4 with Rad53. PMID: 23564203
5. Dbf4 has unique fold necessary for interaction with Rad53 kinase. PMID: 22130670
6. dbf4(7A) is a bona fide intra-S phase checkpoint bypass allele that contributes to abrogating the Rad53 block of origin firing in response to genotoxic stress. PMID: 21098477
7. Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction PMID: 21036905
8. Data document the role of DBF4 as a key player in nitrogen-containing bisphosphonate-induced cytotoxicity, thus explaining the effects on the cell-cycle. PMID: 19744312
9. CDC7 and DBF4 encode the essential Cdc7-Dbf4 protein kinase required for DNA replication in eukaryotes from yeast to human. PMID: 15342501
10. alteration of the M motif may facilitate the role of Dbf4 as a checkpoint target PMID: 16107698
11. identified an expanded and conserved approximately 100-residue N-terminal region of Dbf4p that includes motif N but is capable of encoding a single BRCT-like domain PMID: 16547092
12. Budding yeast Mcm4 is phosphorylated in vivo during S phase in a manner dependent on the presence of five CDK phosphoacceptor residues within the N-terminal domain of Mcm4. PMID: 18321994
13. A complete native data set of the N-terminus of Dbf4 (motif N)was collected at 100 K from crystals that diffracted X-rays to 2.75 A resolution. PMID: 19724125

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KEGG: sce:YDR052C

STRING: 4932.YDR052C