DCP2 Antibody

1. This recruitment requires Hrr25 kinase activity and the Dcp2 decapping enzyme, a core constituent of these RNP granules. Interestingly, the data indicate that this localization sequesters active Hrr25 away from the remainder of the cytoplasm and thereby shields this enzyme from the degradation machinery during these periods of stress. PMID: 27182950
2. Results show that C-terminal domain of Dcp2 includes a set of conserved negative and positive regulatory elements reveal a pivotal role for the Dcp2 in mRNA decapping and lead to a new model for decapping enzyme regulation in vivo. PMID: 26184073
3. Local active site conformational changes are important for Dcp2 mRNA decapping activity. PMID: 23911090
4. show using NMR that cap binds conserved residues on both the catalytic and regulatory domains of Dcp2. PMID: 20711189
5. Ste20 has an unexpected role in the modulation of mRNA decay and translation in Saccharomyces cerevisiae. Phosphorylation of Dcp2 by Ste20 is an important control point for mRNA decapping. PMID: 20513766
6. These results raise a model for Dcp2 recruitment to specific mRNAs where regions outside the catalytic core promote the formation of different complexes involved in mRNA decapping. PMID: 20086104
7. To understand regulation of Dcp2 by ligand interactions, we have assigned the backbone and sidechain methyl Ile (delta1), Leu and Val chemical shifts of the catalytic domain. PMID: 19636815

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KEGG: sce:YNL118C

STRING: 4932.YNL118C