DCP2

DCP2, short for decapping mRNA 2, is a core enzyme in eukaryotic mRNA decay. It catalyzes the removal of the 5' cap from mRNA, triggering 5'-to-3' degradation. Also known as mRNA-decapping enzyme 2, it localizes to processing bodies (P-bodies) and interacts with DCP1A to regulate mRNA stability, critical for gene expression control and cellular homeostasis.
Abnormal DCP2 expression links to breast and colorectal cancers, where dysregulated mRNA decay fuels tumor proliferation. Drug development targets its catalytic activity; small-molecule inhibitors are preclinically explored to disrupt aberrant mRNA metabolism, offering potential anticancer therapeutics.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DCP2 Antibody (CSB-PA810265ESR1HU)

Validated Data

Western blot
All lanes: m7GpppN-mRNA hydrolase antibody at 7μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49, 45 kDa
Observed band size: 49 kDa

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA810265ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA810265ESR1HU at dilution of 1:100

The following DCP2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

DCP2 Antibodies

DCP2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA810265LA01HU	DCP2 Antibody	Human	ELISA, IHC
CSB-PA810265ESR1HU	DCP2 Antibody	Human	ELISA, WB, IHC

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DCP2

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