DICER Antibody

Datasheet
Code CSB-PA747602XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q6TV19
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) DICER protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Endoribonuclease Dicer (EC 3.1.26.3) dicer1
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names dicer1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity).
Subcellular Location Cytoplasm
Protein Families Helicase family, Dicer subfamily
Database Links

KEGG: dre:324724

STRING: 7955.ENSDARP00000045880

UniGene: Dr.78137

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