DICER1

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

DICER1 Antibodies

DICER1 Antibodies for Homo sapiens (Human)

DICER1 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

DICER1 Proteins

DICER1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

DICER1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

DICER1 Proteins for Gallus gallus (Chicken)

DICER1 Proteins for Bos taurus (Bovine)

DICER1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

DICER1 Proteins for Mus musculus (Mouse)

DICER1 Proteins for Homo sapiens (Human)

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