Dkk2 Antibody

Code CSB-PA865601XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Dkk2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Dkk2 antibody; Dickkopf-related protein 2 antibody; Dickkopf-2 antibody; Dkk-2 antibody; mDkk-2 antibody
Raised in
Species Reactivity
Mus musculus (Mouse)
Recombinant Mus musculus (Mouse) Dkk2 protein
Immunogen Species
Mus musculus (Mouse)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Gene References into Functions
  1. Dkk2 deletion results in alterations of liver morphology leading to an increased frequency of liver cancer PMID: 25826080
  2. Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development. PMID: 27053129
  3. These findings demonstrate that DKK1 and DKK2 have differential roles in normalization and functionality of tumor blood vessels, in addition to angiogenesis. PMID: 24091497
  4. Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation PMID: 23250216
  5. Both Dkk1 and Dkk2 inhibit Wnt signaling that regulates early myocardial proliferation; each compensates for loss of the other in that role. PMID: 20439124
  6. there are distinct functions of DKK1 and DKK2 in controlling angiogenesis PMID: 21540552
  7. Dkk2 was localized in the perichondral mesenchyme outlining the anterior cranial base in embryogenesis. PMID: 16521043
  8. Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium PMID: 16672341
  9. These data suggest that activation of Dkk2 by PITX2 provides a mechanism to locally suppress canonical Wnt signaling activity during eye development PMID: 18367164
  10. analysis of the structural basis of the interaction between Dkk and low density lipoprotein receptor-related protein (LRP) 5/6 PMID: 18524778
  11. Dkk2 expression is associated with uterine receptivity changes as well as the process of decidualization and that it might play important roles through inhibition of canonical Wnt signaling in the periimplantation uterus. PMID: 18689976
  12. Study identified novel expression domains for the Wnt antagonists Sfrp1, Sfrp3, Sfrp5 as well as Dkk2 and Dkk3. PMID: 19185060

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Subcellular Location
Protein Families
Dickkopf family
Database Links
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