Dkkl1 Antibody

Code CSB-PA870787XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Dkkl1 Polyclonal antibody
Uniprot No.
Target Names
Dkkl1
Alternative Names
Dkkl1 antibody; Sgy1Dickkopf-like protein 1 antibody; Protein soggy-1 antibody; SGY-1 antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Dkkl1 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Gene References into Functions
  1. Dkkl1 may not be essential for normal brain organization, but could exert import functions during pathological conditions such as tumorigenesis and cancer progression. PMID: 23295900
  2. DKKL1/Dkkl1 may play an important role in testicular development and spermatogenesis and may be an important factor in male infertility. PMID: 22817830
  3. DKKL1 is a mammalian-specific acrosomal protein that is not essential either for development or fertility. PMID: 19596310
  4. DKKL1 is a mammalian-specific, acrosomal protein that strongly affects in vitro fertilization, although the effect is attenuated in vivo. PMID: 19596312
  5. Dkkl1 is a negative regulator of adult testis homeostasis that specifically controls the number of postpubertal spermatocytes. PMID: 18818293
  6. SLY1 interacts with acrosomal protein DKKL1, histone acetyltransferase KAT5 & microtubule-associated protein APPBP2; data suggest SLY1 may be involved in spermiogenesis processes, including control of gene expression & acrosome development or function PMID: 19176879

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Subcellular Location
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.
Tissue Specificity
Testis-specific. Abundant in the seminiferous tubules where it is associated with developing spermatocytes. Expressed only in testis (at protein level). Not detectable on postnatal days 4 and 9 but after day 18 it gradually increased as the development of
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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