EBAG9 Antibody

Datasheet
Code CSB-PA007355ZA01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) EBAG9 Polyclonal antibody
Uniprot No. O00559
Target Names EBAG9
Alternative Names BAG9 antibody; Cancer associated surface antigen antibody; Cancer associated surface antigen RCAS1 antibody; Cancer-associated surface antigen RCAS1 antibody; EB9 antibody; EBAG 9 antibody; EBAG9 antibody; Estrogen receptor binding fragment associated gene 9 protein antibody; Estrogen receptor binding site associated antigen 9 antibody; estrogen receptor binding site associated; antigen; 9 antibody; Estrogen receptor-binding fragment-associated gene 9 protein antibody; PDAF antibody; RCAS 1 antibody; RCAS1 antibody; RCAS1_HUMAN antibody; Receptor binding cancer antigen expressed on SiSo cells antibody; Receptor-binding cancer antigen expressed on SiSo cells antibody
Raised in Rabbit
Species Reactivity Homo sapiens
Immunogen Recombinant Human Receptor-binding cancer antigen expressed on SiSo cells (EBAG9), partial (28-213AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

Target Data

Function May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
Gene References into Functions
  1. Data suggest that joint detection of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) and carcinoembryonic antigen (CEA) can improve the diagnostic sensitivity and specificity. PMID: 26438059
  2. RCAS1 seems to be involved in creating tumor-induced inflammation in the tumor and its microenvironment PMID: 25773455
  3. High EBAG9 expression is associated with malignant pleural effusion in patients with lung cancer. PMID: 24720371
  4. Findings suggest that the histological effect of increased RCAS1 expression depends on its cellular source and that RCAS1 expression itself is a component of various signaling pathways in urothelial bladder cancer cells. PMID: 25674852
  5. suggests that RCAS1 has an apoptotic function via membranous/soluble expression pattern in OSCC cells. RCAS1 may thus affect tumor escape from immune surveillance in OSCC by inducing apoptosis PMID: 24885040
  6. RCAS1 could be a useful immunohistochemical biomarker, indicating not only tumor aggressiveness but also a poorer prognosis for patients with NSCLC. PMID: 24815841
  7. High EBAG9 expression is associated with tamoxifen resistance in breast cancer. PMID: 24119785
  8. sRCAS1 levels could have a clinical value for the diagnosis and management of lung cancer and could be used as a new tumor marker of lung cancer. PMID: 23881387
  9. RCAS1 may play an important role in the phenomenon of tumor escape from host immunological surveillance and in creating the immune tolerance for the tumor cells, as well as in the tumor microenvironment. PMID: 23164108
  10. The membrane molecule RCAS1 induces immune cell apoptosis via the RCAS1-RCAS1R pathway. PMID: 23563217
  11. The intensity of the suppressive profile of the cervical cancer microenvironment indicated by the presence of both RCAS1 and B7H4 on the front of the tumor and in the macrophages and fibroblasts infiltrating the cancer stroma PMID: 22530960
  12. RCAS1 protein may participate in thyroid neoplastic transformation and could be considered as a useful biomarker to improve diagnostic scrutiny. PMID: 22460085
  13. The immunoreactivity of RCAS1 on the cells present in the ovarian cancer microenvironment, was analysed. PMID: 21845402
  14. Data suggest that RCAS1 may be involved in the early stages of tumor progression in mobile tongue squamous cell carcinoma. PMID: 21804460
  15. We observed a statistically significant increase in the RCAS1-positive macrophage infiltration within the microenvironment of the molar lesions in patients with partial hydatidiform mole in comparison with those who exhibited complete hydatidiform mole. PMID: 20645939
  16. analyzed RCAS-1 as a biomarker in the serum of patients with head and neck squamous cell carcinoma PMID: 20571277
  17. EBAG9 acts as a negative regulator of a COPI-dependent ER-to-Golgi transport pathway in epithelial cells and shows pathogenetic principle in which interference with intracellular membrane trafficking results in the emergence of a tumor-associated glycome PMID: 20570965
  18. RCAS1 can be used as a serum tumor marker for diagnosis of pancreatic cancer. PMID: 19957811
  19. the RCAS1 putative receptor-expressing chronic myelogenous leukemia cell line K562 was co-cultured with SiSo, MCF-7, or soluble RCAS1 to follow RCAS1 secretion in apoptosis initiation PMID: 20079734
  20. NASP and RCAS1 proteins were more frequently expressed in ovarian cancer tissues than with normal ovarian tissue and serous cystadenomas and MRE11 was less frequently expressed PMID: 20164540
  21. Overrepresentation of EBAG9 may play a specific role in early stages of breast carcinogenesis. PMID: 11705872
  22. High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker PMID: 11992411
  23. RCAS1 is associated with ductal breast cancer progression PMID: 12054692
  24. modulates surface expression of tumor-associated, normally cryptic O-linked glycan structures and contributes indirectly to the antigenicity of tumor cells PMID: 12672804
  25. RCAS1 expressed on macrophages may play an important role in the induction of activated T-cell apoptosis in cases of HNL PMID: 12774924
  26. Overexpression of EBAG9 is correlated with advanced pathologic stages of prostate cancer PMID: 12845666
  27. RCAS1 may have role endometrial cancer invasiveness; overexpression associated with significantly poorer prognosis PMID: 12888828
  28. RCAS1 gene or protein expression may not correlate with tumor progression in esophageal squamous cell carcinoma PMID: 14534714
  29. The mean survival of patients who had primary hepatocellular carcinoma with high RCAS1 protein expression was significantly longer than that of patients with low expression. PMID: 14981953
  30. wide distribution of EBAG9 and its relation to advanced disease suggest that this protein may play important roles in epithelial ovarian cancer PMID: 15164121
  31. RCAS1 expression might be associated with progression of oral squamous cell carcinoma PMID: 15254686
  32. Serum RCAS1 appears to be valuable as a diagnostic index for biliary carcinomas, as well as for evaluating the progression of cancers during therapy. PMID: 15460847
  33. EBAG9 and Snapin have roles in controlling exocytosis processes PMID: 15635093
  34. Macrophages may negatively regulate erythropoiesis at least in part through the production of RCAS1 molecules. PMID: 15813909
  35. EBAG9 is a crucial regulator of tumor progression and a potential prognostic marker for RCC. PMID: 15867365
  36. the estrogen-inducible EBAG9 gene-product and the 22-1-1 defined antigen are structurally and functionally separate antigens PMID: 15904507
  37. RCAS1 expression is informative for the follow-up of malignant mesothelioma patients and sRCAS1 in pleural fluid may be useful for the diagnosis of malignant mesothelioma. PMID: 16012715
  38. RCAS1 may contribute to acquisition of malignant uterine cervical phenotypic characteristics including invasion, metastasis, and tumor growth via connective tissue remodeling. PMID: 16112176
  39. RCAS1 and CAP may play a role in the downregulation of the maternal immune response during pregnancy and may participate in the initiation of the labor PMID: 16113565
  40. distribution of RCAS1 expression in normal female genital organs; significant positive correlation between age and RCAS1 expression; RCAS1 may affect metaplastic processes and tumor progression PMID: 16175077
  41. expression of RCAS1 is correlated with recurrence not only in carcinomas, but also in mesenchymal tumors PMID: 16211275
  42. metastatic lymph nodes from bile duct, gastric, colon and pancreatic cancer were investigated for RCAS1 expression PMID: 16273616
  43. RCAS1 expression in gliomas may play roles in tumor progression and tumor immune escape. PMID: 16595162
  44. The expression of RCAS1 by endometrial cells may favor the persistence of these cells in ectopic localization both in scar following cesarean section and in ovarian endometriosis. PMID: 16907986
  45. Significantly higher RCAS1 expression was noticed in tumor in comparison to stroma in patients with the presence of lymph nodes metastases. No such difference was observed in patients without the metastases. PMID: 17187007
  46. RCAS1 expression was simultaneous to the infiltration of activated immunological cells of tumor environment as well as decidua. The activity of immunological cells was selectively suppressed. PMID: 17187008
  47. High-level expression of RCAS1 is involved in the malignant transformation of endometrium, and RCAS1 coexpression with ER-alpha may be associated with development and metastasis of endometrial carcinoma PMID: 17466050
  48. The expression of RCAS1 in cervical cancer is significantly increased, and has correlation with malignant degree of cervical carcinoma. Some RCAS1-positive cervical cancer tissues are infected by HPV16. PMID: 17562271
  49. possible role of the RCAS1 protein in the development of pre-eclampsia through an immunological pathway. PMID: 17604121
  50. the drop of the RCAS1 level, which could be a result of an insufficiency of the compensatory immune response mechanisms in tubal mucosa (although these mechanisms are simultaneously preserved in endometrium), leads to tubal perforation. PMID: 17717421
  51. Results show that the suppression of RCAS1 expression effectively recover T cell proliferation, reduce apoptosis and partially reverse the T cell function of IFN-gamma secretion. PMID: 17825484
  52. The limited immune cells infiltration in decidua during severe pre-eclampsia is associated with increase in RCAS1 decidual level. PMID: 17845206
  53. RCAS1 may be a pivotal regulator of tumor growth through angiogenesis. PMID: 17849467
  54. RCAS1 is a bioactive marker that induces connective tissue remodeling and lymphocyte apoptosis [review] PMID: 17981616
  55. The presence of an enhanced number of immune cells of higher activity in ectopic decidua during the final step of decidualization seems to be associated with an increase in the immunoreactivity level of RCAS1. PMID: 18032910
  56. The lowest level of RCAS1 endometrial expression was found during the early secretory cycle phase, and significantly higher expression was found in the endometrium during the mid-secretory as compared to the early secretory cycle phase. PMID: 18292826
  57. In rheumatoid arthritis, the lack of RCAS1 is thought to induce CTL infiltration through loss of the ability to evade immune attack, thus leading to apoptosis of the synovial lining cells. PMID: 18688918
  58. EBAG9 may have a role in promoting progression of bladder cancer PMID: 19030177
  59. The level of RCAS1 in the decidua seems to influence effectiveness of stillbirth induction. PMID: 19032612
  60. The lack of alterations in the sRCAS1 blood serum concentration levels observed in patients with adenomyosis may favor the development of the condition PMID: 19122463
  61. tissue RCAS1 expression...considered as an informative biomarker in several types of human malignancy PMID: 19337974
  62. RCAS1 expression is correlated with a decreasing number of vimentin-positive stromal cells in cervical cancer. PMID: 19574770
  63. RCAS1 has a role in advanced colonic neoplasms PMID: 19634109
  64. We found expression of RCAS1 co-localizing with GFAP+ cells of gliomas and with CD68 and CD74 in large macrophages infiltrating metastatic and primary tumours and sometimes in cells which had morphological characteristics of microglia PMID: 19813143

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Subcellular Location Golgi apparatus membrane, Single-pass type III membrane protein
Tissue Specificity Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
Database Links

HGNC: 3123

OMIM: 605772

KEGG: hsa:9166

STRING: 9606.ENSP00000337675

UniGene: Hs.409368

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