ERCC3 Antibody

Datasheet
Code CSB-PA767240XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q7ZVV1
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) ERCC3 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias TFIIH basal transcription factor complex helicase XPB subunit (EC 3.6.4.12) (DNA excision repair protein ERCC-3) ercc3
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names ercc3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular Location Nucleus
Protein Families Helicase family, RAD25/XPB subfamily
Database Links

KEGG: dre:324323

STRING: 7955.ENSDARP00000105166

UniGene: Dr.6574

Pathway DNA repair pathway

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