ESYT1 Antibody

Code CSB-PA866274ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ESYT1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
E Syt1 antibody; E-Syt1 antibody; Esyt1 antibody; ESYT1_HUMAN antibody; Extended synaptotagmin 1 antibody; Extended synaptotagmin like protein 1 antibody; Extended synaptotagmin-1 antibody; FAM62A antibody; Family with sequence similarity 62 (C2 domain containing) member A antibody; Family with sequence similarity 62 member A antibody; KIAA0747 antibody; MBC2 antibody; Membrane bound C2 domain containing protein antibody; Membrane-bound C2 domain-containing protein antibody; Protein FAM62A antibody
Raised in
Species Reactivity
Homo sapiens
Recombinant Homo sapiens ESYT1 protein
Immunogen Species
Homo sapiens (Human)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
Gene References into Functions
  1. a main effect of Ca(2+) on E-Syt1 is to reverse an autoinhibited state and to couple membrane tethering with lipid transport. PMID: 29222176
  2. knockdown of ESYT1 (and family members ESYT2 and ESYT3) significantly decreased ANO1 current density. PMID: 29154949
  3. This study identified and confirmed ESYT1 protein changes within the postsynaptic density in schizophrenia. PMID: 25048004
  4. ESyt2 and ESyt3, but not ESyt1, interact with activated FGFR1. PMID: 25922075
  5. The extended synaptotagmins (E-Syt1, E-Syt2, and E-Syt3) are endoplasmic reticulum-anchored proteins. They form homo- and heteromeric complexes that mediate contacts with the plasma membrane. Such contacts are critically dependent on the presence of PI(4,5)P2 in this membrane and are additionally regulated by cytosolic Ca2+ via the Ca2+-sensing property of E-Syt1. PMID: 23791178
  6. E-Syt1 is a mediator of cancer cell invasion. PMID: 22659450

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Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein.
Protein Families
Extended synaptotagmin family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 29534

KEGG: hsa:23344

STRING: 9606.ENSP00000267113

UniGene: Hs.632729

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