Ets21C Antibody

Datasheet

Code	CSB-PA326915XA01DLU
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes: Ets21C Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa
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Product Details

Uniprot No.

P29776

Target Names

Ets21C

Alternative Names

DNA-binding protein D-ETS-6 Ets21C ETS-6 CG2914

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Ets21C protein (165-334aa)

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

In the production of the Ets21C polyclonal antibody, a recombinant Drosophila melanogaster (Fruit fly) Ets21C protein (amino acids 165-334) is used as the immunogen to elicit an antibody response in a rabbit. The serum collected from the rabbit contains polyclonal antibodies, which are subsequently purified using affinity chromatography. The proficiency of the Ets21C antibody in detecting the Drosophila melanogaster (Fruit fly) Ets21C protein is established through ELISA and WB assays, confirming its suitability for experimental use.

Drosophila melanogaster Ets21C protein is involved in regulating gene expression during development and in response to environmental stimuli. Ets21C is a transcriptional activator that binds to DNA and recruits other proteins to the gene promoter, recruiting the transcriptional machinery and allowing for the transcription of the gene. Ets21C also participates in regulating gene expression by post-translational modifications or by interacting with other proteins.

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Target Background

Gene References into Functions

Data show that Ets21C has a crucial role in the regulation of tumor growth as a loss of function critically reduced tumor growth, whereas an excess of Ets21C further increased tumor size. While Ets21C was shown only with a role in fine-tuning the transcriptional program of neoplastic tumors, results point towards a more fundamental role as activator of a specific set of target genes driving tumor growth and invasion. PMID: 27713480
malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS-domain factor Ets21c and the nuclear receptor Ftz-F1, all acting downstream of Jun-N-terminal kinase. PMID: 26398940
These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila Intestinal Stem Cells PMID: 26683696

Subcellular Location

Nucleus.

Protein Families

ETS family

Tissue Specificity

Embryonic ventral nervous system and 1 pair of neurons in each thoracic segment.

Database Links

KEGG: dme:Dmel_CG2914

STRING: 7227.FBpp0077739

UniGene: Dm.21518

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Ets21C Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background