Eif3i Antibody

Code CSB-PA007538ZA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Eif3i Polyclonal antibody
Uniprot No.
Target Names
Eif3i
Alternative Names
Eif3i antibody; Eif3s2Eukaryotic translation initiation factor 3 subunit I antibody; eIF3i antibody; Eukaryotic translation initiation factor 3 subunit 2 antibody; eIF-3-beta antibody; eIF3 p36 antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus
Immunogen
Recombinant Rattus norvegicus Eif3i protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Subcellular Location
Cytoplasm.
Protein Families
EIF-3 subunit I family
Database Links

KEGG: rno:682390

UniGene: Rn.162577

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