FBW1A Antibody

Code CSB-PA662374XA01MO
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Btrc Polyclonal antibody
Uniprot No. Q3ULA2
Target Names Btrc
Alternative Names Btrc antibody; Fbw1 antibody; Fbxw1 antibody; Fwd1 antibody; Kiaa4123 antibody; F-box/WD repeat-containing protein 1A antibody; Beta-TrCP protein E3RS-IkappaB antibody; Beta-transducin repeat-containing protein antibody; Beta-TrCP antibody; E3RSIkappaB antibody; mE3RS-IkappaB antibody; F-box and WD repeats protein beta-TrCP antibody; HOS antibody; Ubiquitin ligase FWD1 antibody; pIkappaB-E3 receptor subunit antibody
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Immunogen Recombinant Mus musculus (Mouse) FBW1A protein
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

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Target Data

Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins
Gene References into Functions
  1. beta-TrCP regulates the transition from mitosis to meiosis in male germ cells by targeting DMRT1 for degradation. PMID: 28982686
  2. Data indicate a critical physiological function of beta-TRCP in regulating hepatic lipid metabolic homeostasis in part through modulating Lipin1 stability. PMID: 28049764
  3. betaTrCP levels are correlated with imiquimod-induced skin lesion. PMID: 27476970
  4. beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth PMID: 26009993
  5. Erbin as a novel substrate of SAG-betaTrCP E3 ligase. PMID: 26056141
  6. these results clearly suggest that both beta-TrCP- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 to maintain cellular homeostasis. PMID: 21911472
  7. beta-TrCP may be an essential player in UVB induced responses in skin PMID: 21187057
  8. Glycogen synthase kinase 3 phosphorylates a group of Ser residues in the Neh6 domain of mouse Nrf2 that overlap with an SCF/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1-independent manner. PMID: 21245377
  9. LPS appears to destabilize the LPCAT1 protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination. PMID: 21068446
  10. the two beta-TrCP paralogs have a nonredundant role in spermatogenesis PMID: 20194439
  11. anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF(beta-TrCP) PMID: 19933270
  12. Results suggest a role for Btrc in regulating the eventual ratio of resulting differentiated retinal cell types. PMID: 19705444
  13. hnRNP-U engages a highly neddylated active SCF beta-TrCP which dissociates in the presence of a high-affinity substrate, resulting in the ubiquitination of the latter. PMID: 11850407
  14. HOS plays a role in inhibiting cell differentiation and cell transformation PMID: 12151397
  15. b-TrCP controls meiotic and mitotic progression in vivo. PMID: 12791266
  16. beta-TrCP1 contributes to, but is not absolutely required for, the degradation of I kappa B and beta-catenin PMID: 12843402
  17. mammary glands of betaTrcp1(-/-) female mice display a hypoplastic phenotype, whereas no effects on cell proliferation are observed in other somatic cells PMID: 15340078
  18. Cancer cell lines harboring Smad4 point mutations exhibited rapid Smad4 protein degradation due to the effect of SCF(beta-TrCP1), also called Btrc. PMID: 15855639
  19. Results indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induced apoptosis and contributes to GSK-3beta-mediated tumor suppression and chemosensitization. PMID: 17387146
  20. Data show that beta-TrCP2 and beta-TrCP1 target PER2 protein in vitro, and also show that the beta-TrCP binding site of PER2 is recognized by both beta-TrCP1 and beta-TrCP2. PMID: 18782782
  21. Isoforms of beta-transducin repeat containing protein generated by alternative splicing may have different biological roles. PMID: 18929646
  22. results identify IKK2 and beta-TrCP1 as novel regulators of the p53 pathway and suggest that blocking of IKK2 and beta-TrCP1 could be a means of regulating p53 stability and thereby modulating its biological activity PMID: 19196987

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Subcellular Location Cytoplasm, Nucleus
Tissue Specificity Expressed in heart, brain, liver, skeletal muscle and, most strongly, in testis.
Database Links

KEGG: mmu:12234

STRING: 10090.ENSMUSP00000070728

UniGene: Mm.119717

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