Btrc Antibody

Code CSB-PA662374XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Btrc Polyclonal antibody
Uniprot No.
Target Names
Btrc
Alternative Names
Btrc antibody; Fbw1 antibody; Fbxw1 antibody; Fwd1 antibody; Kiaa4123 antibody; F-box/WD repeat-containing protein 1A antibody; Beta-TrCP protein E3RS-IkappaB antibody; Beta-transducin repeat-containing protein antibody; Beta-TrCP antibody; E3RSIkappaB antibody; mE3RS-IkappaB antibody; F-box and WD repeats protein beta-TrCP antibody; HOS antibody; Ubiquitin ligase FWD1 antibody; pIkappaB-E3 receptor subunit antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Btrc protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis. SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. Mediates ubiquitination of REST, thereby leading to its proteasomal degradation. SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis.
Gene References into Functions
  1. beta-TrCP regulates the transition from mitosis to meiosis in male germ cells by targeting DMRT1 for degradation. PMID: 28982686
  2. Data indicate a critical physiological function of beta-TRCP in regulating hepatic lipid metabolic homeostasis in part through modulating Lipin1 stability. PMID: 28049764
  3. betaTrCP levels are correlated with imiquimod-induced skin lesion. PMID: 27476970
  4. beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth PMID: 26009993
  5. Erbin as a novel substrate of SAG-betaTrCP E3 ligase. PMID: 26056141
  6. these results clearly suggest that both beta-TrCP- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 to maintain cellular homeostasis. PMID: 21911472
  7. beta-TrCP may be an essential player in UVB induced responses in skin PMID: 21187057
  8. Glycogen synthase kinase 3 phosphorylates a group of Ser residues in the Neh6 domain of mouse Nrf2 that overlap with an SCF/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1-independent manner. PMID: 21245377
  9. LPS appears to destabilize the LPCAT1 protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination. PMID: 21068446
  10. the two beta-TrCP paralogs have a nonredundant role in spermatogenesis PMID: 20194439
  11. anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF(beta-TrCP) PMID: 19933270
  12. Results suggest a role for Btrc in regulating the eventual ratio of resulting differentiated retinal cell types. PMID: 19705444
  13. hnRNP-U engages a highly neddylated active SCF beta-TrCP which dissociates in the presence of a high-affinity substrate, resulting in the ubiquitination of the latter. PMID: 11850407
  14. HOS plays a role in inhibiting cell differentiation and cell transformation PMID: 12151397
  15. b-TrCP controls meiotic and mitotic progression in vivo. PMID: 12791266
  16. beta-TrCP1 contributes to, but is not absolutely required for, the degradation of I kappa B and beta-catenin PMID: 12843402
  17. mammary glands of betaTrcp1(-/-) female mice display a hypoplastic phenotype, whereas no effects on cell proliferation are observed in other somatic cells PMID: 15340078
  18. Cancer cell lines harboring Smad4 point mutations exhibited rapid Smad4 protein degradation due to the effect of SCF(beta-TrCP1), also called Btrc. PMID: 15855639
  19. Results indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induced apoptosis and contributes to GSK-3beta-mediated tumor suppression and chemosensitization. PMID: 17387146
  20. Data show that beta-TrCP2 and beta-TrCP1 target PER2 protein in vitro, and also show that the beta-TrCP binding site of PER2 is recognized by both beta-TrCP1 and beta-TrCP2. PMID: 18782782
  21. Isoforms of beta-transducin repeat containing protein generated by alternative splicing may have different biological roles. PMID: 18929646
  22. results identify IKK2 and beta-TrCP1 as novel regulators of the p53 pathway and suggest that blocking of IKK2 and beta-TrCP1 could be a means of regulating p53 stability and thereby modulating its biological activity PMID: 19196987

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Subcellular Location
Cytoplasm. Nucleus.
Tissue Specificity
Expressed in heart, brain, liver, skeletal muscle and, most strongly, in testis.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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