Recombinant Mouse F-box/WD repeat-containing protein 1A (Btrc)

1. beta-TrCP regulates the transition from mitosis to meiosis in male germ cells by targeting DMRT1 for degradation. PMID: 28982686
2. Data indicate a critical physiological function of beta-TRCP in regulating hepatic lipid metabolic homeostasis in part through modulating Lipin1 stability. PMID: 28049764
3. betaTrCP levels are correlated with imiquimod-induced skin lesion. PMID: 27476970
4. beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth PMID: 26009993
5. Erbin as a novel substrate of SAG-betaTrCP E3 ligase. PMID: 26056141
6. these results clearly suggest that both beta-TrCP- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 to maintain cellular homeostasis. PMID: 21911472
7. beta-TrCP may be an essential player in UVB induced responses in skin PMID: 21187057
8. Glycogen synthase kinase 3 phosphorylates a group of Ser residues in the Neh6 domain of mouse Nrf2 that overlap with an SCF/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1-independent manner. PMID: 21245377
9. LPS appears to destabilize the LPCAT1 protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination. PMID: 21068446
10. the two beta-TrCP paralogs have a nonredundant role in spermatogenesis PMID: 20194439
11. anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF(beta-TrCP) PMID: 19933270
12. Results suggest a role for Btrc in regulating the eventual ratio of resulting differentiated retinal cell types. PMID: 19705444
13. hnRNP-U engages a highly neddylated active SCF beta-TrCP which dissociates in the presence of a high-affinity substrate, resulting in the ubiquitination of the latter. PMID: 11850407
14. HOS plays a role in inhibiting cell differentiation and cell transformation PMID: 12151397
15. b-TrCP controls meiotic and mitotic progression in vivo. PMID: 12791266
16. beta-TrCP1 contributes to, but is not absolutely required for, the degradation of I kappa B and beta-catenin PMID: 12843402
17. mammary glands of betaTrcp1(-/-) female mice display a hypoplastic phenotype, whereas no effects on cell proliferation are observed in other somatic cells PMID: 15340078
18. Cancer cell lines harboring Smad4 point mutations exhibited rapid Smad4 protein degradation due to the effect of SCF(beta-TrCP1), also called Btrc. PMID: 15855639
19. Results indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induced apoptosis and contributes to GSK-3beta-mediated tumor suppression and chemosensitization. PMID: 17387146
20. Data show that beta-TrCP2 and beta-TrCP1 target PER2 protein in vitro, and also show that the beta-TrCP binding site of PER2 is recognized by both beta-TrCP1 and beta-TrCP2. PMID: 18782782
21. Isoforms of beta-transducin repeat containing protein generated by alternative splicing may have different biological roles. PMID: 18929646
22. results identify IKK2 and beta-TrCP1 as novel regulators of the p53 pathway and suggest that blocking of IKK2 and beta-TrCP1 could be a means of regulating p53 stability and thereby modulating its biological activity PMID: 19196987

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KEGG: mmu:12234

STRING: 10090.ENSMUSP00000070728

UniGene: Mm.119717