fgf1 Antibody

Code CSB-PA754234XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) fgf1 Polyclonal antibody
Uniprot No.
Target Names
fgf1
Alternative Names
fgf1 antibody; fgf-1 antibody; zgc:73249Putative fibroblast growth factor 1 antibody; FGF-1 antibody; Acidic fibroblast growth factor antibody; aFGF antibody; Heparin-binding growth factor 1 antibody; HBGF-1 antibody
Raised in
Rabbit
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) fgf1 protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
Gene References into Functions
  1. Fgf1 was confirmed as the overnutrition-induced beta-cell differentiation signal, as inactivation of fgf1 abolished the compensatory beta-cell differentiation. PMID: 26420862
  2. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina. PMID: 26428010
  3. This study demonistrated that Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish. PMID: 22649227
  4. Data suggest that elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitment into the heart field during evolution, increasing the size of the heart. PMID: 21750034
  5. fgf1 is required for normal differentiation of erythrocytes in zebrafish primitive hematopoiesis. PMID: 17219402

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Subcellular Location
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus.
Protein Families
Heparin-binding growth factors family
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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