FIS1 Antibody

1. Positively charged patch at the carboxyl terminus of Fis1p is required for both membrane insertion and organelle specificity. PMID: 28007883
2. Fis1-E78A at lower expression levels recruits Dnm1 into mitochondrial punctate structures but fails to support normal fission. Thus, Fis1 makes multiple interactions that support Dnm1 puncta formation and may be essential after this step, supporting a revised model for assembly of the mitochondrial fission machinery. PMID: 27496949
3. The lifespan extension caused by deletion of FIS1 is mainly due to a defect in peroxisome fission and not caused by a block in mitochondrial fragmentation. PMID: 25840089
4. 1.75 A resolution crystal structure of the Fis1 cytoplasmic domain from Saccharomyces cerevisiae is reported which adopts a tetratricopeptide-repeat fold PMID: 22102223
5. Charcot-Marie-Tooth-related gene GDAP1 complements cell cycle delay at G2/M phase in Saccharomyces cerevisiae fis1 gene-defective cells PMID: 21890626
6. Ethanol-induced cell death in yeast is Fis1-mediated apoptosis. PMID: 17544409
7. Refinement against the (13)C' T(1)/T(2) improved the overall quality of the yeast Fis1 structure, as evaluated by cross-validation against the residual dipolar coupling as well as the (15)N relaxation data. PMID: 17554496
8. reveal how Fis1 recruits the mitochondrial fission complex and will facilitate efforts to manipulate mitochondrial fission PMID: 17998537
9. Deletion of the FIS1 gene in yeast consistently results in acquisition of a secondary mutation that confers sensitivity to cell death. PMID: 18756280
10. NMR measurements sensitive to dynamics occurring on a wide range of time scales (picoseconds to minutes) were used to assess whether the Fis1 arm is dynamic. PMID: 19522466

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KEGG: sce:YIL065C

STRING: 4932.YIL065C