Fgl2 Antibody

1. These results indicated that FGL2 might be a promising target for attenuating the severity of Severe acute pancreatitis (SAP) and adenovirus-mediated artificial miRNAs targetting FGL2 represented a potential therapeutic approach for the treatment of SAP. PMID: 29054965
2. The results of the present study indicated that, in the colitis model, FGL2 was associated with the immunopathogenesis of inflammatory bowel disease. PMID: 28713999
3. FGL2-overexpressing regulatory T-cells have enhanced immunosuppressive activity and prevent colitis; FGL2-over-expressing effector T-cells are hypo-proliferative and do not induce colitis PMID: 28487604
4. PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 after ICH, and that manipulation of PD-1 might be a promising therapeutical target in ICH. PMID: 27717876
5. In vitro IL-33 treatment abrogated MHV-3 and IFN-gamma induced FGL2 expression in RAW264.7 and THP-1 cells. PMID: 28494352
6. FGL2 appears as one of the key players in immune regulatory processes favoring metacestode survival by promoting Regulatory T-cell activity and IL-17A production that contributes to FGL2-regulation. PMID: 25955764
7. these data strongly suggest that Treg cells expressing FGL2 mediate rapamycin-induced tolerance. Furthermore, a gene biomarker panel that includes fgl2 can distinguish between rejecting and tolerant grafts. PMID: 24990517
8. Mouse susceptibility to MHV-3-induced fulminant hepatitis may rely on C5a/C5aR interactions, for which ERK1/2 and p38 pathways participate in up-regulating Fgl2 expression. PMID: 24604562
9. Targeted deletion of FGL2 leads to increased early viral replication and enhanced adaptive immunity in a murine model of acute viral hepatitis. PMID: 24146739
10. Cysteines at positions 94, 97, 184 and 187, found in the coiled-coil domain were shown to be crucial for FGL2 oligomerization. PMID: 23127799
11. FGL2 binding to the FcgammaRIIB receptor expressed on sinusoidal endothelial cells (SECs) is a critical event in the initiation of the hepatic reperfusion injury cascade through induction of SEC and hepatocyte death. PMID: 21756857
12. The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis. PMID: 21469939
13. Fgl2 cleaves prothrombin to thrombin consistent with serine protease activity and requires calcium, phospholipids, and factor Va for its full activity. PMID: 11994472
14. While membrane-bound Fgl2 acts as a prothrombinase, soluble Fgl2 is an immunomodulatory protein that has the ability to modulate T cell responses and to alter dendritic cell (DC) maturation to favor production of tolerogenic DC. PMID: 12682232
15. fgl2 expression in endothelial cells is controlled by Ets-1 and Oct-1, and requires Sp1 and Sp3 PMID: 12752447
16. Fgl2 is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction. PMID: 14742694
17. Fgl2-deficient and control mice produce similar levels of fibrin, a product of the coagulation cascade, during T. gondii infection and allograft rejection. PMID: 14976252
18. Fgl2 is constitutively absent at baseline in vascular endothelial cells (ECs) of fgl2+/- murine hearts, but is induced in vascular ECs of mouse-to-rat cardiac xenografts undergoing acute vascular rejection with thrombosis. PMID: 15100314
19. Fgl2 expression accounts for the fibrin deposition seen in experimental cardiac allograft rejection; these data provide a rationale for targeting fgl2 as adjunctive therapy to treat allograft rejection. PMID: 15905589
20. Results suggest that virus-induced fibrinogen-like protein 2 prothrombinase/fibroleukin expression and associated coagulation activity play a pivotal role in initiating severe hepatitis. PMID: 16437596
21. FGL2 has a role in susceptibility to mouse hepatitis virus (MHV-3)-induced fulminant hepatitis PMID: 17037572
22. Fgl2 deficiency is not associated with obvious structural cardiac defects but is associated with a high incidence of neonatal death as well as contractile dysfunction and rhythm abnormalities during embryonic and postnatal development in mice PMID: 17550996
23. FGL2 contributes to Treg cell activity and inhibits the development of autoimmune disease. PMID: 18097026
24. FGL2 is an important effector cytokine of egulatory T cells that contributes to susceptibility to mouse hepatitis virus strain 3 induced fulminant viral hepatitis. PMID: 19085958

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KEGG: mmu:14190

STRING: 10090.ENSMUSP00000046131

UniGene: Mm.292100