GRX6 Antibody

1. Crystal structure of Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster has been presented. PMID: 27710937
2. A specific function influenced by Grx6 activity is the homeostasis of intracellular calcium. Grx6-deficient mutants have reduced levels of calcium in the ER lumen, whereas accumulation occurs at the cytosol from extracellular sources. PMID: 25355945
3. Compared to the classic dithiol glutaredoxin Grx1, Grx6 has a lower glutathione disulfide reductase activity but a higher glutathione S-transferase activity. PMID: 20347849
4. S. pombe cells harboring plasmid pFGRX6 containing the Grx6 gene had about 1.3-fold elevated Grx activity in the exponential phase, and grew better than the control cells under some stressful conditions. PMID: 18182845
5. Grx6 and Grx7 do not play a general role in the oxidative folding of proteins in the early secretory pathway but rather counteract the oxidation of specific thiol groups in substrate proteins. PMID: 18400945
6. GRX6 could be responsible for the regulation of the sulfhydryl oxidative state at the oxidant conditions of the early secretory pathway vesicles. PMID: 18503006

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KEGG: sce:YDL010W

STRING: 4932.YDL010W