greA Antibody

Datasheet

Code	CSB-PA998671XA01ENV
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) greA Polyclonal antibody

Uniprot No.

P0A6W5

Target Names

greA

Alternative Names

greA antibody; b3181 antibody; JW3148Transcription elongation factor GreA antibody; Transcript cleavage factor GreA antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) greA protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

Gene References into Functions

overexpression of GreB in DeltagreA cells reduced the misincorporation errors to wild-type levels, demonstrating that GreB at high concentration could substitute for GreA in RNA proofreading activity in vivo. PMID: 28341651
GreA mutations increase the efficiency of RecA-mediated recombination. PMID: 21453489
The greA leader region contains two strong promoters and an unusual terminator that gives rise to two clusters of small RNA chains. PMID: 20008510
The half-life of GreA and GreB proteins suggests the involvement of DnaK and DnaJ in the stability of these proteins. PMID: 15702537
GreA effects on rrnB P1 open complex conformation reveal a new feature of GreA distinct from its general function in elongation. PMID: 16597620
transcript cleavage during early stages of initiation is thus the main in vivo function of GreA. PMID: 17766423
Data show that GreA deficiency enhanced RNAP trapping at most of the newly identified stall sites. PMID: 18333883

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Protein Families

GreA/GreB family

Database Links

KEGG: ecj:JW3148

STRING: 316385.ECDH10B_3355

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