gsk-3 Antibody

Code CSB-PA886973XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans gsk-3 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
gsk-3 antibody; sgg-1 antibody; Y18D10A.5Glycogen synthase kinase-3 antibody; EC antibody
Raised in
Species Reactivity
Caenorhabditis elegans
Recombinant Caenorhabditis elegans gsk-3 protein
Immunogen Species
Caenorhabditis elegans
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension.
Gene References into Functions
  1. In C. elegans germline stem cells, loss of gsk-3 results in reduced germline stem cell proliferation without changes in differentiation or responsiveness to GLP-1/Notch signaling. PMID: 29695611
  2. Rearrangement of mitotic spindles requires the GSK-3 kinase. Apoptotic cell clearance and migration of the distal tip cell require the GSK-3 kinase. PMID: 20126385
  3. (i) GSK-3 inhibits SKN-1 activity in the intestine, (ii) the phase II response integrates multiple regulatory signals, and (iii), by inhibiting this response, GSK-3 may influence redox conditions. PMID: 16251270
  4. GSK3 converts OMA-1 and OMA-2 from being key regulators of oocyte maturation to key regulators of 1-cell embryo development PMID: 16289132
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
Database Links
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