Icos Antibody

Datasheet

Code	CSB-PA889939ZA01RA
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Target Background

Product Details

Full Product Name

Rabbit anti-Rattus norvegicus (Rat) Icos Polyclonal antibody

Uniprot No.

Q9R1T7

Target Names

Icos

Alternative Names

Icos antibody; Ailim antibody; Inducible T-cell costimulator antibody; Activation-inducible lymphocyte immunomediatory molecule antibody; CD antigen CD278 antibody

Raised in

Rabbit

Species Reactivity

Rattus norvegicus

Immunogen

Recombinant Rattus norvegicus Icos protein

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

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Target Background

Function

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Gene References into Functions

ICOS-targeted siRNA can effectively silence gene expression of ICOS, and provided satisfactory treatment efficacy for myocardial cell hypertrophy after infarction. PMID: 27323062
ICOS siRNA can protect brain tissues from ischemia injuries after cerebral infarction, improve limb movement and coordination, lower the mortality rate of rats, and inhibit T cell-induced cytokines PMID: 26436531
our data highlight a key role for ICOS signaling in the generation of imbalanced production of IL-10 and IL-17 by Treg cells in a rat model of spondyloarthritis. PMID: 24909668

Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Strongly expressed in the spleen and lung. Lower expression seen in liver, kidney and testis.

Database Links

KEGG: rno:64545

STRING: 10116.ENSRNOP00000064455

UniGene: Rn.168816

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

T cell receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Icos Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background