JDP2 Antibody

1. In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC and better survival. PMID: 28315425
2. Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells. PMID: 24120378
3. Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE. PMID: 24232097
4. the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism. PMID: 22989952
5. The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed. PMID: 20950777
6. JDP2 is crucial to triggering reactivation from latency to lytic replication PMID: 21525011
7. 3 SNPs (2 intronic: rs741846 & rs175646; & 1 in the untranslated region: rs8215) & their genotype distribution showed significant association in the Japanese & Korean but not Dutch intracranial aneurysm patients. PMID: 20452405
8. JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival. PMID: 20677166
9. c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene PMID: 14627710
10. JDP2 is a cellular survival protein whose presence is necessary for normal cellular function PMID: 16026868
11. JDP2 acts as a repressor and could be functionally associated with HDAC3 to inhibit CHOP transcription PMID: 18396163
12. IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter. PMID: 18671972
13. A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain. PMID: 19553667

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HGNC: 17546

OMIM: 608657

KEGG: hsa:122953

STRING: 9606.ENSP00000267569

UniGene: Hs.196482