KCC2A Antibody

Code CSB-PA004465XA01MO
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Camk2a Polyclonal antibody
Uniprot No. P11798
Target Names Camk2a
Alternative Names Camk2aCalcium/calmodulin-dependent protein kinase type II subunit alpha antibody; CaM kinase II subunit alpha antibody; CaMK-II subunit alpha antibody; EC 2.7.11.17 antibody
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Immunogen Recombinant Mus musculus (Mouse) KCC2A protein
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

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Target Data

Function CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. Phosphorylates transcription factor FOXO3 on 'Ser-298' (By similarity). Activates FOXO3 transcriptional activity
Gene References into Functions
  1. Fluorescence resonance energy transfer studies confirm that the extended state of CaMKII-alpha resolved by electron microscopy is the predominant form of the holoenzyme, even under molecular crowding conditions. PMID: 28589927
  2. Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII/CREB signaling pathway in a motion sickness rodent model. PMID: 28230177
  3. Its pathway may promote reactive oxygen species generation in the early state Alzheimer's disease and eventually contribute to the exacerbation of pathological phenotype. PMID: 29602494
  4. Study showed the significance of TLR4 in upregulation of MAPK/ErK in NMDAR hypofunction schizophrenic-mouse model. This is characterized by a decrease in hippocampal IGF-1R/CaMKIIalpha, and social interaction behavioral deficits. Ultimately, hippocampal TLR4 knockdown rescued IGF-1R/CaMKIIalpha decline and prevented behavioral deficits by reducing MAPK/ErK expression. PMID: 29137928
  5. Hyperlipidemia induced by a high-fat diet was associated with increased expression and activity of CaMKII in heart. PMID: 28662005
  6. Data show that calcium/calmodulin protein kinase II (CaMKII)-mediated modulation of neuronal sodium current impacts neuronal excitability in SCN2A sodium channel alpha subunit Scn2a(Q54) mice and may represent a therapeutic target for the treatment of epilepsy. PMID: 28137877
  7. Results show that aging impairs the training-induced upregulation of autophosphorylated (T286) alphaCaMKII in the CA3 stratum radiatum of the hippocampus. This indicates that distinct age-related mechanisms underlie CFC that may rely more heavily on NMDA receptor-dependent plasticity in young age. PMID: 28648815
  8. This study found that the Camk2a gene showed a downregulated profile only in the Inflexible when compared to the Light ethanol drinkers group. PMID: 28714806
  9. Results suggest that the increased expression of calcium/calmodulin dependent protein kinase II in the lateral habenula is instrumental for morphine-driven aversive behaviors. PMID: 28527717
  10. our findings demonstrated that TINCR could attenuate myocardial hypertrophy by epigenetically silencing of CaMKII, which may provide a novel therapeutic strategy for cardiac hypertrophy. PMID: 28548932
  11. CaMKII is a target of PTENalpha phosphatase and that PTENalpha is an essential element in the molecular regulation of neural activity. PMID: 28636948
  12. In FHC-linked TnT-mutated hearts, RyR2 is susceptible to CaMKII-mediated phosphorylation, presumably because of a mutation-linked increase in diastolic [Ca(2+)]i, causing aberrant Ca(2+) release leading to lethal arrhythmia. PMID: 29402414
  13. Data suggest that alphaCaMKII autophosphorylation-dependent remodeling of glutamatergic synapses is a plausible mechanism for the regulation of the alcohol addiction-related behaviors. PMID: 26572936
  14. astrocytic IL-17A plays important roles in the maintenance of neuropathic pain through CaMKII/CREB signaling pathway in spinal cord. PMID: 26166359
  15. Wip1 phosphatase plays a vital role in regulating hippocampal synaptic plasticity by modulating the phosphorylation of CaMKII. PMID: 27158969
  16. Destabilization of PGC1a is attributable to decreased p38 MAPK activation via diminished CaMKII signaling. Thus, we elucidate a pathway downstream of Ca(2+)-mediated CaMKII activation that is dysfunctional in C3KO(Capn3 knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation PMID: 27005420
  17. In young mice, 30% of adult CaMKIIalpha expression is sufficient for normal long-term potentiation in the hippocampus and cerebral cortex. PMID: 27535377
  18. Findings demonstrate that Thr286 phosphorylation of CaMKII plays an important role in induction of long-term potentiation (LTP) by integrating Ca(2+) signals, and it greatly promotes, but is dispensable for, the activation of CaMKII and LTP. PMID: 28521133
  19. The present study demonstrates, for the first time, that ROS-dependent activation of CaMKII mediates altered Ca2+ handling and contractile dysfunction observed in the setting of sepsis. PMID: 27648519
  20. these data implicate the importance of subunit stoichiometry as another regulatory mechanism of PKA activity and lipid metabolism. PMID: 27496951
  21. Thus, taken into consideration the mechanism that controls the upregulation of maturation genes involved in synaptic formation, these results indicate that Etv1 orchestrates the activity-dependent regulation of both maturation and immaturation genes in developing granule cells and plays a key role in specifying the identity of mature granule cells in the cerebellum. PMID: 27059140
  22. Pharmacological and genetic studies using CaMKII antagonists and genetically modified [alpha]-CaMKII mice have shown that blockade or reduction of CaMKII reduces nicotine reward PMID: 26292186
  23. The study shows advanced glycation end products (AGEs) resulted from ribosylation activate calcium-/calmodulin-dependent protein kinase type II (CaMKII), a key kinase responsible for Tau hyperphosphorylation. PMID: 26095350
  24. HDAC2 may regulate the expression of immediate early genes, in part, by prolonging the actions of pCREB in the mouse nucleus accumbens. PMID: 26300473
  25. The results suggest that CaMKII-dependent TnI phosphorylation is involved in FDMCD and the consequent FDAR and that CaMKII inhibition removes this mechanism and thus induces diastolic dysfunction. PMID: 26297240
  26. Results indicate that alpha-Ca(2+)/calmodulin-dependent protein kinase II overexpression in the forebrain impairs behavioral flexibility and NMDAR-dependent long-term depression in the medial prefrontal cortex. PMID: 26415772
  27. As up-regulation of epithelial barriers is essential for the prevention of chronic inflammatory diseases, the identification of CaMKII as a modulator of TJ function paves the way for the development of new drugs to treat these diseases. PMID: 26281891
  28. Binge-like drinking decreased Camk2a phosphorylation in amygdala from adolescent mice, with no effect in adult mice. PMID: 26247621
  29. This study show that CaMKII regulates the flow of sensory information in Abeta-LTMR sensory neurons at multiple levels, including impulse generation, Action potential propagation, and dorsal horn synaptic transmission PMID: 26490852
  30. CaMKIIalpha selectively regulates mGluR1a and mGluR5a ERK1/2 signaling. PMID: 25885040
  31. Results identify CaMKII isoform phosphorylation sites and a network of synaptic protein interactions that are sensitive to the abrogation of Thr286 autophosphorylation of CaMKIIa PMID: 25650780
  32. Results suggest that inhibitory autophosphorylation of CAMKIIa regulates the threshold for induction of both long-term potentiation and long-term depression PMID: 24480420
  33. showed polypyrimidine tract binding protein (PTBP)-dependent alternative splicing of CaMKIIalpha transcripts in the lens PMID: 25540577
  34. Ca2+/calmodulin-dependent protein kinase-II (CaMKII) has a key role in the plasticity of glutamatergic synapses of the brain. PMID: 25290264
  35. VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation. PMID: 25644714
  36. Genetic deletion of Camk2a impaired the locomotor response of mice to ecstasy. PMID: 26019340
  37. IRBIT suppresses CaMKIIalpha activity and contributes to catecholamine homeostasis through TH phosphorylation. PMID: 25922519
  38. Our results demonstrate unanticipated, fundamentally important roles for UNC-43/CaMKII in the regulation of synaptic strength. PMID: 25843407
  39. results provide new mechanistic insight into the role of alphakap in regulating the stability of the postsynaptic apparatus of neuromuscular synapses. PMID: 25834039
  40. data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII activation. PMID: 25834051
  41. Angiotensin II activates PKA and CaMKII via NOX2, which results in disturbed sodium and calcium currents (via PKA) and enhanced diastolic sarcoplasmic reticulum Calcium leakage. PMID: 25073061
  42. Data show that resolvin D1 decrease nuclear 5-lipoxygenase (5-LOX) and the leukotrienes LTB4:LXA4 ratio by macrophages lacking calcium-sensitive kinase calcium-calmodulin-dependent protein kinase II (CaMKII). PMID: 25246560
  43. Therefore, these studies reveal a novel interaction between CAPN3 and CaM and identify CaM as the first positive regulator of CAPN3 activity PMID: 25389288
  44. Calmodulin and PI(3,4,5)P cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production. PMID: 25097034
  45. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. PMID: 24949568
  46. Aging increases both the oxidation and CaMKII-phosphorylation of RyR2, which results in calcium leak and atrial fibrillation initiation. PMID: 24576293
  47. This study demonistrated that the requirement for alphaCaMKII in the forebrain, but not the cerebellum, in spatial and contextual learning. PMID: 25143599
  48. Data indicate that nitric oxide directly affects Ca-calmodulin-dependent protein kinase (CaMKII) to sustain its activity leading to the increase in sarcoplasmic reticulum calcium leak. PMID: 24498331
  49. Loss of alpha-CaMKII from adult-generated granule cells is associated with impaired hippocampus-dependent learning. PMID: 25186740
  50. Our study presents novel evidence that CaMKII expression in vivo is regulated by a negative feedback loop following oxidative activation. PMID: 24418021

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Subcellular Location Isoform Alpha KAP: Cytoplasm, Cell junction, synapse, presynaptic cell membrane, Cell junction, synapse
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Tissue Specificity Isoform Alpha CaMKII is expressed in brain while isoform Alpha KAP is expressed in skeletal muscle.
Database Links

KEGG: mmu:12322

STRING: 10090.ENSMUSP00000099952

UniGene: Mm.131530

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