scrib Antibody

1. the simultaneous loss of the asymmetric cell division regulators Canoe (afadin in mammals) and Scribble in neuroblast clones leads to tumor-like overgrowth through both a severe disruption of the asymmetric cell division process and canoe loss-mediated Ras-PI3K-Akt activation PMID: 28619817
2. the effects of loss of scrib and the modification of these effects via cooperative interactions that enhance the overall tumorigenic potential of scrib deficient cells, is reported. PMID: 27327956
3. Knocking down scribble expression in either Mushroom body neurons or Dopaminergic neurons impairs normal memory loss. PMID: 27263975
4. Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo. PMID: 25005475
5. Drosophila scrib acts downstream of the Fat (Ft) receptor, and requires Hippo signaling for its growth regulatory functions. PMID: 23144804
6. Loss of Scrib promotes Yorkie/Scalloped-dependent epithelial tissue overgrowth, and this is also important for driving cooperative tumor overgrowth with oncogenic Ras-Raf signaling. PMID: 21955824
7. Data show that mutations causing the loss of Salvador (Sav) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules. PMID: 20432470
8. These results demonstrate distinct aPKC and JNK-dependent pathways through which loss of Scrib promotes tumourigenesis in Drosophila. PMID: 19778415
9. Scrib is essential for olfactory behavior in D. melanogaster. PMID: 12930751

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KEGG: dme:Dmel_CG43398

STRING: 7227.FBpp0300852

UniGene: Dm.16441