lin-61 Antibody

Code CSB-PA976108XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans lin-61 Polyclonal antibody
Uniprot No.
Target Names
lin-61
Alternative Names
lin-61 antibody; R06C7.7Protein lin-61 antibody; Abnormal cell lineage protein 61 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans lin-61 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability.
Gene References into Functions
  1. Using a novel reporter system that monitors repair of a defined DSB in C. elegans somatic cells, we show that LIN-61 contributes to homologous recombination . PMID: 23505385
  2. H3K9me2/3 interaction of LIN-61 is required for C. elegans vulva development within the synMuvB pathway PMID: 21437264
  3. These data indicate that while the class B synMuv genes act together to regulate vulval development, lin-61 functions separately from some class B synMuv proteins in other biological processes. PMID: 17409073
Subcellular Location
Nucleus. Chromosome.
Database Links

KEGG: cel:CELE_R06C7.7

STRING: 6239.R06C7.7b

UniGene: Cel.17247

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