Lyz2 Antibody

Code CSB-PA357518ZA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Lyz2 Polyclonal antibody
Uniprot No.
Target Names
Lyz2
Alternative Names
Lysozyme C-2 (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (Lysozyme C type M), Lyz2, Lyz Lyzs
Raised in
Rabbit
Species Reactivity
Mus musculus
Immunogen
Recombinant Mus musculus Lyz2 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugate
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria.
Gene References into Functions
  1. Results show that lysozyme (LYSO) - induced Staphylococcus aureus bacteriostasis increased with increasing concentrations of baicalin, and that baicalin binding to LYSO synergistically increased the antibacterial activity of LYSO. PMID: 28184027
  2. Data show that receptor-interacting serine-threonine kinase 3 (RIPK3) deletion prevents inflammatory phenotypes in CreLysM (lysozyme M) Casp8fl/fl (caspase 8) mice. PMID: 26471282
  3. Depletion of LysM(+) cells attenuated ATII-induced blood pressure increase. PMID: 21875910
  4. ApoE and lysozyme M have roles in monocyte and neutrophil trafficking in atherosclerosis in a mouse model PMID: 18508059
  5. P-tau was found in medial entorhinal cortex of Naglu(-/-) mice, in the same neurons as lysozyme PMID: 19416848

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Subcellular Location
Secreted.
Protein Families
Glycosyl hydrolase 22 family
Tissue Specificity
Expressed weakly in myeloblasts, moderately in immature macrophages, and strongly in both mature macrophages and macrophage-rich tissues.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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