MCM10 Antibody

1. This report demonstrates that Mcm10, an essential replication protein unique to eukaryotes, binds the replicative helicase CMG and greatly stimulates its helicase activity in vitro. Most significantly, Mcm10 enables CMG and the replisome to bypass blocks on the non-tracking DNA strand. PMID: 28869037
2. These data suggest that DNA binding by Mcm10 is essential for the initiation of DNA replication. PMID: 27751725
3. Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair. PMID: 24674891
4. In the absence of Mcm10, a stable Cdc45-Mcm-GINS (CMG) complex was assembled at origins. However subsequent translocation of CMG, replication protein A loading to origins, and the intra-S checkpoint activation were severely diminished. PMID: 22285032
5. These data indicate that Ctf4p facilitates Mcm10p to promote the DNA replication. PMID: 20381454
6. Mcm10 plays two important roles as a linker of the MCM helicase and Polalpha at the elongating replication fork--first, to coordinate the activities of these two molecular motors PMID: 19917723
7. required for the presence of DNA pol I at replication forks and may coordinate DNA synthesis with DNA unwinding PMID: 15494305
8. Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae. PMID: 16085704
9. Mcm10 mutants disrupt mating loci silencing and Mcm10 interacts with Sir2 and Sir3, suggesting that Mcm10 plays an essential, and separable role in transcriptional silencing. PMID: 16328881
10. Mcm10 is required for the coupling of the replication and silencing machineries to silence chromatin in a context outside of DNA replication beyond the recruitment and spreading of Sir2 on chromatin. PMID: 19064704
11. analysis of DNA binding properties of the Mcm10 protein from Saccharomyces cerevisiae PMID: 19605346

Show More

Hide All

KEGG: sce:YIL150C

STRING: 4932.YIL150C