MPC1 Antibody

1. Low MPC1 expression is associated with epithelial-mesenchymal transition in cholangiocarcinoma. PMID: 29286150
2. Levels of lactate and mitochondrial pyruvate carrier (MPC1) mRNA were determined to scrutinize the prevalence of aerobic glycolysis..MT-RNR2 plays its anti-apoptotic role partly by avoiding deploying energy from complete oxidation of organic compounds to inorganic wastes. Thus MT-RNR2 can potentially serve as a new biomarker in the diagnosis of bladder carcinoma especially that it is present in blood circulation PMID: 28462847
3. Low MPC1 expression is associated with prostate cancer. PMID: 26895100
4. Utilizing zebrafish to examine the genetic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorectal cancer, the authors found that apc controls the levels of mpc1 and that knock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differentiation. PMID: 28397687
5. GTPBP3 plays a role in the regulation of MCP1 protein through AMPK signaling. PMID: 26642043
6. genetic studies of 3 families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1 (BRP44L) changing single amino acids that are conserved throughout eukaryotes; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier PMID: 22628558

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HGNC: 21606

OMIM: 614738

KEGG: hsa:51660

STRING: 9606.ENSP00000354223

UniGene: Hs.172755