MPS1 Antibody

1. An important role for Mps1 phosphorylation in the spindle assembly checkpoint activation, beyond the direct recruitment of Mad1 and Mad2. PMID: 27280788
2. CCT271850 is a potent, selective and orally bioavailable MPS1 kinase inhibitor. On the basis of in vivo pharmacodynamic vs efficacy relationships, we predict that more than 80% inhibition of MPS1 activity for at least 24 h is required to achieve tumour stasis or regression by CCT271850. PMID: 28334731
3. These findings highlight MPS1 as a rational therapeutic target for medulloblastoma PMID: 27633003
4. Disrupting Mps1 before mitotic entry reduces chromosomal passenger complex (CPC) localization to the centromere. Mps1 plays a minimal role in maintaining CPC localization once cells are in mitosis. PMID: 25854549
5. Mps1 kinase controls Cnn1 localization and activity at kinetochores through the cell cycle. PMID: 25716979
6. Ipl1 released these improper connections, whereas Mps1 triggered the formation of new force-generating microtubule attachments. PMID: 23371552
7. found that Sgo1 overexpression rescues defects caused by metaphase inactivation of Mps1 and that Mps1 is required for Sgo1 localization to the kinetochore PMID: 21389114
8. Mps1 plays an important role in kinetochore attachment during mitotic spindle assembly and function. PMID: 15668173
9. it was demonstrated that mutual inhibition between the anaphase-promoting complex (APC) and Mps1, an essential component of the checkpoint, leads to sustained inactivation of the spindle checkpoint PMID: 16825537
10. Phosphorylation of Dam1 residues S218 and S221 by Mps1 is required for efficient coupling of kinetochores to microtubule plus ends. PMID: 16890524
11. Mps1 promotes re-orientation of kinetochore-spindle pole connections and eliminates those that do not generate tension between sister kinetochores. PMID: 18060784
12. Results suggest that a putative Mps1-dependent phosphorylation of Ndc80 is important for spindle assembly checkpoint activation at kinetochores. PMID: 19300438

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KEGG: sce:YDL028C

STRING: 4932.YDL028C