MRE11 Antibody

Code CSB-PA339299XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MRE11 Polyclonal antibody
Uniprot No. P32829
Target Names MRE11
Alternative Names MRE11 antibody; YMR224C antibody; YM9959.06C antibody; Double-strand break repair protein MRE11 antibody
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MRE11 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
Gene References into Functions
  1. error-prone BIRs are increased in homeologous recombination in wild-type and in mre11A470T cells. PMID: 29705126
  2. Resection of DNA breaks is impaired when either Sae2 activity is blocked, suggesting roles for both Mre11 and Sae2 nuclease activities in promoting the processing of DNA ends in vivo. PMID: 28970327
  3. A major DSB sensor, the Mre11-Rad50-Xrs2 (MRX) complex, is regulated by cell cycle-dependent phosphorylation specifically in mitosis. PMID: 24553123
  4. propose that Mre11 nuclease- and Sae2-dependent DNA end processing, which initiates DSB resection prevents Ku from engaging DSBs, thus promoting Exo1-dependent resection PMID: 21876003
  5. results identify a function for MRE11 in the response to topoisomerase poisons that is distinct from its functions in DSB repair or meiotic DNA processing PMID: 21060845
  6. Mre11 mutation promotes telomere recombination and an efficient bypass of senescence. PMID: 20421597
  7. Mre11 nuclease activity is essential for resection in the absence of extensive double-strand break end resection enzymes. PMID: 20834227
  8. Mre11 mutations are associated with increased rates of spontaneous loss of heterozygosity leading to genome instability. PMID: 20410660
  9. The nuclease function of Mre11 is required for RMX-mediated recombinational repair and telomere stabilization in mitotic cells. PMID: 15126391
  10. Mre11 nuclease is not involved in the extensive 5' to 3' resection of double-strand breaks PMID: 15485933
  11. Rad50 hook is critical for Mre11 complex-dependent DNA repair, telomere maintenance and meiotic double-strand break formation PMID: 15852023
  12. Srs2 and Sgs1 associate with Mre11 in different subcomplexes following checkpoint abd CDK1-mediated Srs2 phosphorylation. PMID: 15964827
  13. These data suggest that Mre 11p can act as a positive and negative regulator of TRD in context of the MRX complex that is essential for TRD. PMID: 15990364
  14. S.cerevisiae Mre11 protein possesses high binding affinity for G4 DNA and cleaves G-rich sequences. PMID: 16116037
  15. Mutations in Mre11 phosphoesterase motif I impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. PMID: 16143598
  16. Mre11/Rad50 complexes from three organisms catalyze the reversible adenylate kinase reaction in vitro. PMID: 17349953
  17. Mre11 is involved in the regulation of a specific class of genes during spore development through its C-terminus domain. PMID: 17396017
  18. Mre11 nuclease and C-terminal tail-mediated DDR functions are required for initiating yeast telomere healing. PMID: 18335232

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Subcellular Location Nucleus.
Protein Families MRE11/RAD32 family
Database Links

KEGG: sce:YMR224C

STRING: 4932.YMR224C

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