MSH5 Antibody

Code CSB-PA015031XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MSH5 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
DKFZp434C1615 antibody; G7 antibody; hMSH5 antibody; MGC2939 antibody; MSH 5 antibody; MSH5 antibody; MSH5_HUMAN antibody; mutS (E. coli) homolog 5 antibody; mutS homolog 5 antibody; mutS homolog 5 (E. coli) antibody; MutS protein homolog 5 antibody; MutSH5 antibody; NG23 antibody; OTTHUMP00000029187 antibody; OTTHUMP00000029188 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) MSH5 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.
Gene References into Functions
  1. From sanger sequencing of MSH5 in 200 sporadic POI patients, we identified three heterozygous mutations . Considering the heterozygous p.D487Y carrier in the POI pedigree was fertile, the causality of the three heterozygous mutations in POI need more evidence PMID: 28175301
  2. our data point to the existence of a functional interplay between hMSH5 and FANCJ in double-strand break repair induced by replication stress. PMID: 26055704
  3. the roles of hMSH5 variants in the processes of DNA damage response and repair PMID: 24023853
  4. Authors show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells. PMID: 22917773
  5. Study has suggested a role for hMSH5 in the processing of cisplatin-induced DSBs, and silencing of hMSH5 may provide a new means to improve the therapeutic efficacy of cisplatin. PMID: 22401567
  6. The presence of the MSH5 85F allele marks the subgroup of DRB1*0102 haplotypes carrying susceptibility for selective IgA deficiency. MSH5 polymorphisms per se are not predisposing factors. PMID: 20542071
  7. hMSH5 possesses a CRM1-dependent nuclear export signal and a nuclear localization signal that participates to its nuclear targeting. PMID: 20185565
  8. There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility PMID: 19808033
  9. A review of the properties and functional roles of MSH5. PMID: 17127347
  10. These findings suggest that Msh4/5 heterodimers contribute to class switch recombination. PMID: 17409188
  11. Data show that MSH5 mutations may be one explanation for premature ovarian failure. PMID: 18166824
  12. Biochemical identification of the proteins with which it interacted showed that SMCY formed a distinct complex with MSH5, a critical meiosis-regulatory protein in the human testicular germ cell line, NEC8. PMID: 18459961
  13. this study implicates a role for hMSH5 in DNA damage response involving c-Abl and p73, and suggests that mutations impairing this process could significantly affect normal cellular responses to anti-cancer treatments. PMID: 19442657
  14. occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918

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Involvement in disease
Premature ovarian failure 13 (POF13)
Protein Families
DNA mismatch repair MutS family
Tissue Specificity
Widely expressed, with high levels in testis and ovary, including granulosa cells. Also expressed in fetal ovary and adrenal gland.
Database Links

HGNC: 7328

OMIM: 603382

KEGG: hsa:4439

STRING: 9606.ENSP00000364855

UniGene: Hs.647011

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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