MSH5 Antibody

1. From sanger sequencing of MSH5 in 200 sporadic POI patients, we identified three heterozygous mutations . Considering the heterozygous p.D487Y carrier in the POI pedigree was fertile, the causality of the three heterozygous mutations in POI need more evidence PMID: 28175301
2. our data point to the existence of a functional interplay between hMSH5 and FANCJ in double-strand break repair induced by replication stress. PMID: 26055704
3. the roles of hMSH5 variants in the processes of DNA damage response and repair PMID: 24023853
4. Authors show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells. PMID: 22917773
5. Study has suggested a role for hMSH5 in the processing of cisplatin-induced DSBs, and silencing of hMSH5 may provide a new means to improve the therapeutic efficacy of cisplatin. PMID: 22401567
6. The presence of the MSH5 85F allele marks the subgroup of DRB1*0102 haplotypes carrying susceptibility for selective IgA deficiency. MSH5 polymorphisms per se are not predisposing factors. PMID: 20542071
7. hMSH5 possesses a CRM1-dependent nuclear export signal and a nuclear localization signal that participates to its nuclear targeting. PMID: 20185565
8. There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility PMID: 19808033
9. A review of the properties and functional roles of MSH5. PMID: 17127347
10. These findings suggest that Msh4/5 heterodimers contribute to class switch recombination. PMID: 17409188
11. Data show that MSH5 mutations may be one explanation for premature ovarian failure. PMID: 18166824
12. Biochemical identification of the proteins with which it interacted showed that SMCY formed a distinct complex with MSH5, a critical meiosis-regulatory protein in the human testicular germ cell line, NEC8. PMID: 18459961
13. this study implicates a role for hMSH5 in DNA damage response involving c-Abl and p73, and suggests that mutations impairing this process could significantly affect normal cellular responses to anti-cancer treatments. PMID: 19442657
14. occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918

Show More

Hide All

HGNC: 7328

OMIM: 603382

KEGG: hsa:4439

STRING: 9606.ENSP00000364855

UniGene: Hs.647011