Myb Antibody

Code CSB-PA356215XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Myb Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Myb antibody; CG9045 antibody; Myb protein antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Myb protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes.
Gene References into Functions
  1. Myb transcriptionally regulates cytokinesis. PMID: 23438598
  2. Dm myb and grim are both involved in regulating PCD in two distinct settings suggests that these two genes may often work together to mediate PCD. PMID: 22960039
  3. Dampened transcriptional activation by E2F1-DP and Myb-MuvB is important to repress mitosis and coordinate the endocycle transcription. PMID: 21045111
  4. controls G2/M progression by inducing cyclin B expression PMID: 11847115
  5. findings imply that Dm-Myb provides an essential nontranscriptional function during chromosomal replication PMID: 12032301
  6. Drosophila myb exerts opposing effects on S phase, promoting proliferation and suppressing endoreduplication. PMID: 12223407
  7. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication PMID: 12490953
  8. DmMyb activates a repressive complex containing Mip130 into a complex competent to support DNA replication at specific loci in a temporally and developmentally proscribed manner. PMID: 15256498
  9. examination of linking together the Myb and E2F2 complexes in higher-order assembly to specific chromosomal sites for the regulation of transcription PMID: 15545624
  10. The essential roles of Myb are executed as part of a switching mechanism that is dependent on DNA sites and developmental context. PMID: 17978103
  11. Cell cycle specific degradation of Drosophila Myb is likely to be utilized as a key regulatory mechanism in down-regulating the activity of the Myb complex. PMID: 18424081

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Subcellular Location
Nucleus. Chromosome.
Database Links

KEGG: dme:Dmel_CG9045

STRING: 7227.FBpp0089402

UniGene: Dm.2907

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