MTM1 Antibody

Code CSB-PA911338XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) MTM1 Polyclonal antibody
Uniprot No.
Target Names
MTM1
Alternative Names
MTM1 antibody; At3g10550 antibody; F13M14.17 antibody; F18K10.13 antibody; Phosphatidylinositol-3-phosphatase myotubularin-1 antibody; AtMTM1 antibody; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase antibody; EC 3.1.3.95 antibody; Phosphatidylinositol-3-phosphate phosphatase antibody; EC 3.1.3.64 antibody
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana MTM1 protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Phosphatase with phosphoinositide 3'-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus. Required for recovery after water deprivation, via the accumulation of PtdIns5P upon dehydration; high PtdIns5P levels mediate ATX1 cytoplasmic localization, thus down-regulating the expression of ATX1-dependent genes. Confers sensitivity to soil-water-deficit stress.
Gene References into Functions
  1. AtMTM1 is involved in elevating the cellular level of phosphatidylinositol 5-phosphate in response to dehydration stress. PMID: 22324391
  2. AtMTM1 encodes a phosphoinositide 3′-phosphatase related to the animal myotubularins. AtMTM1 and the Arabidopsis chromatin modifier ATX1, co-regulate overlapping set of genes under drought conditions. [AtMTM1] PMID: 19901554
  3. study reports that At3g10550, encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins (AtMTM1); identifed an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions PMID: 19901554
Subcellular Location
Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Present in granular particles of varying abundance and size at the cell periphery and throughout the cytoplasm.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Tissue Specificity
Mostly expressed in siliques and leaves (including hydathodes), and, to a lower extent, in flowers and roots.
Database Links

KEGG: ath:AT3G10550

STRING: 3702.AT3G10550.1

UniGene: At.46683

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