| Code | CSB-PA801264ZA01HU |
| Size |
Pls inquirePurchase it in Cusabio online store (only available for customers from the US) |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) NRROS Polyclonal antibody |
| Uniprot No. | Q86YC3 |
| Target Names | NRROS |
| Alternative Names | NRROS antibody; LRRC33 antibody; UNQ3030/PRO9833Transforming growth factor beta activator LRRC33 antibody; Leucine-rich repeat-containing protein 33 antibody; Negative regulator of reactive oxygen species antibody |
| Raised in | Rabbit |
| Species Reactivity | Homo sapiens |
| Immunogen | Recombinant Homo sapiens NRROS protein |
| Immunogen Species | Homo sapiens (Human) |
| Conjugate | Non-conjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Protein A/G |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
| Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
| Lead Time | Made-to-order (12-14 weeks) |
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| Function (From Uniprot) |
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling. |
| Gene References into Functions |
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| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Mainly expressed in cells of hematopoietic origin. Highly expressed in bone marrow, thymus, liver, lung, intestine and spleen. In the brain, highly expressed in microglia. |
| Database Links |
HGNC: 24613 OMIM: 615322 KEGG: hsa:375387 STRING: 9606.ENSP00000328625 UniGene: Hs.702186 |
