Nthl1 Antibody

Code CSB-PA016125XA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Nthl1 Polyclonal antibody
Uniprot No.
Target Names
Nthl1
Alternative Names
Nthl1 antibody; Nth1 antibody; Endonuclease III-like protein 1 antibody; EC 3.2.2.- antibody; EC 4.2.99.18 antibody; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase antibody; DNA glycosylase/AP lyase antibody
Raised in
Rabbit
Species Reactivity
Mus musculus (Mouse)
Immunogen
Recombinant Mus musculus (Mouse) Nthl1 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Gene References into Functions
  1. These results suggest that Nth1 plays an important role in telomere maintenance and base repair against oxidative stress-induced base modifications. PMID: 23874233
  2. deficiencies in Ogg1 and/or Nth1 do not lead to decreased DNA double strand breaks PMID: 22536455
  3. To determine the significance of thymine glycol repair in mammals, a mouse model with mutated mNth1, a homolog of nth, was made by gene targeting. Mutant mouse liver, instead of mNTH1 activity, had at least 2 novel DNA glycosylase activities against Tg. PMID: 12093749
  4. To determine the role of murine Nth1 in protecting genomic integrity, a knockout strain was created. No phenotypic changes from wild type were noted due to a novel AP endonuclease DNA repair system. PMID: 12167705
  5. NEIL1 is a back-up glycosylase for NTH1 with unique substrate specificity and tissue-specific expression PMID: 12200441
  6. the mechanism for the removal of 5,6-dihydrouracil from DNA by mNTH1-deficient cell-free extracts derived from testes of mNTH1 knock-out mice PMID: 12401779
  7. mNTH1 is responsible for the repair of thymine glycols in mitochondrial DNA PMID: 12819227
  8. ability of nth1 to discriminate between thymine glycol stereoisomers PMID: 14726482
  9. results indicated that 8-oxoguanine DNA-glycosylase (OGG1) and nth (endonuclease III)-like 1(NTH1) are the major DNA glycosylases for the removal of 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA) PMID: 16221681

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Subcellular Location
Nucleus. Mitochondrion.
Protein Families
Nth/MutY family
Tissue Specificity
Widely expressed.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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