Endonuclease III-like protein 1 is a protein in humans that is encoded by NTHL1 gene. Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
The following NTHL1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NTHL1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA016125GA01HU | NTHL1 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA016125LA01HU | NTHL1 Antibody |
Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA016125LB01HU | NTHL1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA016125LC01HU | NTHL1 Antibody, FITC conjugated |
Human | |
CSB-PA016125LD01HU | NTHL1 Antibody, Biotin conjugated |
Human | ELISA |
NTHL1 Antibodies for Gallus gallus (Chicken)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA108707XA01CH | NTHL1 Antibody |
Gallus gallus (Chicken) | ELISA, WB (ensure identification of antigen) |
NTHL1 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA016125XA01MO | Nthl1 Antibody |
Mus musculus (Mouse) | ELISA, WB (ensure identification of antigen) |
NTHL1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP016125HU CSB-EP016125HU CSB-BP016125HU CSB-MP016125HU CSB-EP016125HU-B |
Recombinant Human Endonuclease III-like protein 1 (NTHL1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTHL1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP016125MO CSB-EP016125MO CSB-BP016125MO CSB-MP016125MO CSB-EP016125MO-B |
Recombinant Mouse Endonuclease III-like protein 1 (Nthl1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTHL1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP643445BO CSB-EP643445BO CSB-BP643445BO CSB-MP643445BO CSB-EP643445BO-B |
Recombinant Bovine Endonuclease III-like protein 1 (NTHL1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |