Ntsr1 Antibody

1. A thermostable variant termed enNTS1 exhibited the best combination of signaling capability and stability upon solubilization with detergents. Several well dispersed (13)CH3-methionine resonances were seen by solution NMR spectroscopy, many of which exhibited chemical shift changes upon the addition of the high affinity agonist peptide, NT8-13. PMID: 29596791
2. Herein potential interaction between NTS1 receptor, dopaminergic D2 receptor and Na(+), K(+)-ATPase was studied.Results indicated that typical and atypical antipsychotic drugs differentially modulate the interaction between neurotensin and Na(+), K(+)-ATPase. PMID: 27586561
3. NTS1 agonists as potentially novel drugs for the treatment of schizophrenia. PMID: 26783230
4. Molecular dynamics simulations of NTS1 in bilayers are in agreement with the ESR data, and point to sites in the receptor where PS could interact with higher affinity PMID: 26926422
5. Molecular dynamics simulation study on the neurotensin peptide receptor NTSR1 with neurotensin bound, with the aim of understanding the structural basis of thermostabilization and activation PMID: 25807267
6. This study demonistrated that Ntsr1 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain. PMID: 24978951
7. Maternal separation-induced alternations of DNA methylation in the promoter region of NTSR1 in the amygdala may be associated with vulnerability to the development of anxiety disorders and depression in adulthood PMID: 24831231
8. the crystal structure at 2.8 A resolution of Rattus norvegicus NTSR1 in an active-like state, bound to NTS(8-13), the carboxy-terminal portion of NTS responsible for agonist-induced activation of the receptor PMID: 23051748
9. The high-affinity NT receptor may not be involved in ligand binding inhibition to muscarinic receptor by NT. PMID: 20403392
10. NTR1-like immunoreactive GABAergic neurons are widely distributed in the deep layers of the prefrontal cortex. NTR1 may play a role in PFC interneuron regulation by neurotensin. PMID: 15716398
11. Data showed a positive correlation between blood ethanol concentration and higher neurotensin receptor 1 density in putamen and ventral midbrain in High and Low Alcohol Sensitive rat lines. PMID: 16953387
12. Neurotensin 1 receptors play a key role in the regulation of pain signaling in the spinal cord. PMID: 18182046
13. The potentiating effects of neurotensin on DA and 5-HT release in the PFC are regulated by NTR1 receptors, probably located on dopaminergic and serotonergic nerve terminals or axons. PMID: 18835308

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KEGG: rno:366274

STRING: 10116.ENSRNOP00000035997

UniGene: Rn.200149