NTSR1

NTSR1, or neurotensin receptor 1, alias NTR1, NTRH, neurotensin receptor type 1 and so on. It is a G protein-coupled receptor (GPCR), which belongs to the large superfamily of G protein-coupled receptors.The main source of NTSR1 is the gene coding of human cells themselves, and it is widely distributed in the brain, spinal cord and peripheral tissues. Its mechanism of action involves binding to neurohypocretin and mediating different cellular signaling events through activation of the classical signaling pathway of G proteins, as well as binding to β-arrestins, thus exerting a variety of biological functions within the cell.

NTSR1 has a wide range of biological significance, and is involved in the regulation of a variety of physiological processes, including blood pressure regulation, temperature control, pain perception, gastrointestinal motility and Activation of NTSR1 can induce physiological effects such as hypotension, hyperglycemia, hypothermia, and anti-injury effects. In addition, abnormal function of NTSR1 has been associated with certain diseases, such as schizophrenia, trigeminal neuroma, and pancreatic cancer. Therefore, NTSR1 is a potential target in drug development and disease treatment, especially its allosteric modulator SBI-553, as a novel modulator, has shown potential for the treatment of psychostimulant abuse in animal models, which provides new ideas for the development of safer GPCR-targeted therapeutic drugs.