rho Antibody

Code CSB-PA019681XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) rho Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
rho; zfo2; Rhodopsin
Raised in
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) rho protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling.
Gene References into Functions
  1. The efficiency of CRISPR/Cas9 for gene targeting, coupled with the large number of mutations associated with retinitis pigmentosa, provided a backdrop for the rapid isolation of novel alleles in zebrafish that phenocopy disease. PMID: 30210230
  2. overexpression of full-length rhodopsin or its cytoplasmic tail domain, but not of rhodopsin lacking the cytoplasmic tail, exacerbated rod degeneration in kif3a mutants, implying an important role of the cytoplasmic tail in rod degeneration. PMID: 28855254
  3. expression as well as the protein localization of rhodopsin in the zebrafish from larval to adult stage were demonstrated; results demonstrated the involvement of rhodopsin in the zebrafish pineal gland physiology particularly in light capture during the zebrafish lifespan PMID: 22306032
  4. Mitogen-associated protein kinase and protein kinase A regulate rhodopsin transcription through parallel signal transduction pathways PMID: 17183589
Subcellular Location
Membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment.
Protein Families
G-protein coupled receptor 1 family, Opsin subfamily
Tissue Specificity
Retinal rod photoreceptor cells, predominantly in the outer segments (at protein level). Retinal rod photoreceptor cells.
Database Links

KEGG: dre:30295

STRING: 7955.ENSDARP00000011562

UniGene: Dr.354

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