Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) REXO2 Polyclonal antibody

Uniprot No.

Q9Y3B8

Target Names

REXO2

Alternative Names

1810038D15Rik antibody; AW107347 antibody; CGI 114 antibody; DKFZP566E144 antibody; MGC105914 antibody; MGC111570 antibody; mitochondrial antibody; Oligoribonuclease antibody; Oligoribonuclease, mitochondrial [Precursor] antibody; ORN_HUMAN antibody; REX2, RNA exonuclease 2 homolog (S. cerevisiae) antibody; REXO2 antibody; RFN antibody; RNA exonuclease 2 antibody; RNA exonuclease 2 homolog antibody; SFN antibody; Small fragment nuclease antibody; Smfn antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) REXO2 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development.; 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.

Gene References into Functions

results demonstrate that 14-3-3sigma induces cisplatin resistance in esophageal squamous cell carcinoma cells PMID: 26346170
CBY1 downregulation in CML arises from reduced protein stability upon binding to 14-3-3sigma adapter protein. The ubiquitin proteasome system UPS participates in reducing stability of CBY1 bound with 14-3-3sigma through enhanced SUMOylation. PMID: 26147002
Loss of 14-3-3sigma sensitizes cells to UVB. After a transient cell cycle arrest, 14-3-3sigma-deficient cells die by undergoing mitotic catastrophe. PMID: 24102700
REXO2 is an oligoribonuclease active in human mitochondria and present both in cytosolic and mitochondrial fractions. PMID: 23741365
SFN expression is involved in resistance of RSa cells to UV-C-induced cell death through the roles it plays in the DNA repair process PMID: 15362935
The expression in E. coli of orn and homologues from Mycobacterium smegmatis and human, and large-scale purification of the three enzymes, is reported. PMID: 18023590

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Subcellular Location

Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion. Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.

Protein Families

Oligoribonuclease family

Tissue Specificity

Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus.

Database Links

HGNC: 17851

OMIM: 607149

KEGG: hsa:25996

STRING: 9606.ENSP00000265881

UniGene: Hs.677190

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REXO2 Antibody

Product Details

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Target Background