Product Details

Purity

>85% (SDS-PAGE)

Target Names

ORN

Uniprot No.

Q9Y3B8

Alternative Names

Oligoribonuclease, mitochondrial; EC 3.1.15.-; RNA exonuclease 2 homolog; Small fragment nuclease; REXO2 SFN SMFN CGI-114

Species

Homo sapiens (Human)

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development.; 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.

Gene References into Functions

results demonstrate that 14-3-3sigma induces cisplatin resistance in esophageal squamous cell carcinoma cells PMID: 26346170
CBY1 downregulation in CML arises from reduced protein stability upon binding to 14-3-3sigma adapter protein. The ubiquitin proteasome system UPS participates in reducing stability of CBY1 bound with 14-3-3sigma through enhanced SUMOylation. PMID: 26147002
Loss of 14-3-3sigma sensitizes cells to UVB. After a transient cell cycle arrest, 14-3-3sigma-deficient cells die by undergoing mitotic catastrophe. PMID: 24102700
REXO2 is an oligoribonuclease active in human mitochondria and present both in cytosolic and mitochondrial fractions. PMID: 23741365
SFN expression is involved in resistance of RSa cells to UV-C-induced cell death through the roles it plays in the DNA repair process PMID: 15362935
The expression in E. coli of orn and homologues from Mycobacterium smegmatis and human, and large-scale purification of the three enzymes, is reported. PMID: 18023590

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Subcellular Location

Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion. Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.

Protein Families

Oligoribonuclease family

Tissue Specificity

Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus.

Database Links

HGNC: 17851

OMIM: 607149

KEGG: hsa:25996

STRING: 9606.ENSP00000265881

UniGene: Hs.677190

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Recombinant Human Oligoribonuclease, mitochondrial (REXO2 SFN SMFN CGI-114)

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